RPS15A [The Human Chemical-Genetic Interaction Map Project]

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======= RPS15A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS15A
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S15a
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6210|6210]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62244|P62244]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS15A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS15A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603674|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosolic small ribosomal subunit|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|response to virus|
|protein targeting|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|translation|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|intracellular protein transport|
|macromolecule catabolic process|
|regulation of cell cycle|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-3.01|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.4|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.33|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.17|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.1|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.05|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.98|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.87|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.84|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.83|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.82|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.76|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.74|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.71|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.72|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.73|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.73|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.77|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.8|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.81|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.82|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.85|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.89|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.89|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.9|
|[[:results:exp303|39°C R06 exp303]]|1.92|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.04|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.06|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.08|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.09|
|[[:results:exp453|B02 10μM R08 exp453]]|2.3|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.44|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 732/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 475
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS15A Expression in NALM6 Cells: 8.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>