RPS19BP1 [The Human Chemical-Genetic Interaction Map Project]

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======= RPS19BP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS19BP1
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S19 binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91582|91582]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WX3|Q86WX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS19BP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS19BP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610225|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. {ECO:0000269|PubMed:17964266}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enzyme binding|
|nucleolus|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.8|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.71|
|[[:results:exp453|B02 10μM R08 exp453]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kctd17|KCTD17]]|0.532|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.525|
|[[:human genes:c:chaf1a|CHAF1A]]|0.518|
|[[:human genes:t:tfip11|TFIP11]]|0.513|
|[[:human genes:c:ccna2|CCNA2]]|0.513|
|[[:human genes:i:ik|IK]]|0.513|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.503|
|[[:human genes:t:tceb3c|TCEB3C]]|0.501|
|[[:human genes:c:cdca3|CDCA3]]|0.501|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.501|
|[[:human genes:h:hivep3|HIVEP3]]|0.5|
|[[:human genes:c:crnkl1|CRNKL1]]|0.5|
|[[:human genes:p:psmb4|PSMB4]]|0.498|
|[[:human genes:s:ssh2|SSH2]]|0.498|
|[[:human genes:c:cope|COPE]]|0.498|
|[[:human genes:p:prpf8|PRPF8]]|0.497|
|[[:human genes:w:wdr43|WDR43]]|0.496|
|[[:human genes:o:orc6|ORC6]]|0.494|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.493|
|[[:human genes:w:wdr87|WDR87]]|0.492|
|[[:human genes:r:rpl35|RPL35]]|0.49|
|[[:human genes:c:cbwd5|CBWD5]]|0.489|
|[[:human genes:n:npipb5|NPIPB5]]|0.488|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.487|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.484|
|[[:human genes:o:orc1|ORC1]]|0.483|
|[[:human genes:r:rad51|RAD51]]|0.483|
|[[:human genes:r:rps2|RPS2]]|0.483|
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
|[[:human genes:a:acsf2|ACSF2]]|0.482|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.481|
|[[:human genes:c:cbwd3|CBWD3]]|0.479|
|[[:human genes:c:chd4|CHD4]]|0.477|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.476|
|[[:human genes:s:supt5h|SUPT5H]]|0.476|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.475|
|[[:human genes:n:nol12|NOL12]]|0.475|
|[[:human genes:p:psmd3|PSMD3]]|0.472|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.47|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.47|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.47|
|[[:human genes:n:npipb4|NPIPB4]]|0.469|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.469|
|[[:human genes:t:ticrr|TICRR]]|0.467|
|[[:human genes:p:pole|POLE]]|0.464|
|[[:human genes:v:vasn|VASN]]|0.464|
|[[:human genes:i:igfn1|IGFN1]]|0.463|
|[[:human genes:u:upf1|UPF1]]|0.463|
|[[:human genes:n:nupl1|NUPL1]]|0.462|
|[[:human genes:r:rpl37a|RPL37A]]|0.46|
|[[:human genes:r:rpl34|RPL34]]|0.459|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.458|
|[[:human genes:s:snrpa1|SNRPA1]]|0.456|
|[[:human genes:r:rps12|RPS12]]|0.455|
|[[:human genes:m:mbtd1|MBTD1]]|0.453|
|[[:human genes:c:cln6|CLN6]]|0.452|
|[[:human genes:r:rrp15|RRP15]]|0.452|
|[[:human genes:m:madcam1|MADCAM1]]|0.45|
|[[:human genes:c:cactin|CACTIN]]|0.448|
|[[:human genes:t:tspy8|TSPY8]]|0.448|
|[[:human genes:p:psmc6|PSMC6]]|0.445|
|[[:human genes:c:cdc45|CDC45]]|0.444|
|[[:human genes:d:dock6|DOCK6]]|0.443|
|[[:human genes:k:krt78|KRT78]]|0.443|
|[[:human genes:r:rrp7a|RRP7A]]|0.44|
|[[:human genes:r:rrn3|RRN3]]|0.439|
|[[:human genes:n:nup153|NUP153]]|0.439|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.438|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.438|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.437|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.437|
|[[:human genes:m:mtch2|MTCH2]]|0.436|
|[[:human genes:d:dtl|DTL]]|0.435|
|[[:human genes:c:cbwd6|CBWD6]]|0.434|
|[[:human genes:p:plk4|PLK4]]|0.434|
|[[:human genes:o:ogfr|OGFR]]|0.434|
|[[:human genes:t:twistnb|TWISTNB]]|0.433|
|[[:human genes:s:slc4a1|SLC4A1]]|0.433|
|[[:human genes:s:sap30bp|SAP30BP]]|0.433|
|[[:human genes:g:golga6a|GOLGA6A]]|0.433|
|[[:human genes:e:exd1|EXD1]]|0.432|
|[[:human genes:s:snrnp70|SNRNP70]]|0.432|
|[[:human genes:s:specc1l|SPECC1L]]|0.432|
|[[:human genes:l:loc643669|LOC643669]]|0.428|
|[[:human genes:s:snip1|SNIP1]]|0.427|
|[[:human genes:r:rps5|RPS5]]|0.427|
|[[:human genes:u:utp3|UTP3]]|0.426|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.426|
|[[:human genes:f:fbxw9|FBXW9]]|0.426|
|[[:human genes:e:exosc5|EXOSC5]]|0.426|
|[[:human genes:v:vps28|VPS28]]|0.425|
|[[:human genes:r:riok2|RIOK2]]|0.424|
|[[:human genes:p:paf1|PAF1]]|0.424|
|[[:human genes:c:cep192|CEP192]]|0.424|
|[[:human genes:p:psmd1|PSMD1]]|0.423|
|[[:human genes:s:supt6h|SUPT6H]]|0.423|
|[[:human genes:m:mt1e|MT1E]]|0.422|
|[[:human genes:d:ddtl|DDTL]]|0.422|
|[[:human genes:a:arcn1|ARCN1]]|0.422|
|[[:human genes:n:nipbl|NIPBL]]|0.422|
|[[:human genes:p:polr2a|POLR2A]]|0.422|
|[[:human genes:p:plekha4|PLEKHA4]]|0.422|
|[[:human genes:r:rnpc3|RNPC3]]|0.421|
|[[:human genes:r:rps28|RPS28]]|0.421|
|[[:human genes:p:pola1|POLA1]]|0.421|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.419|
|[[:human genes:n:nufip2|NUFIP2]]|0.419|
|[[:human genes:p:psmd6|PSMD6]]|0.419|
|[[:human genes:c:copb1|COPB1]]|0.418|
|[[:human genes:i:iscu|ISCU]]|0.418|
|[[:human genes:z:znf830|ZNF830]]|0.418|
|[[:human genes:s:sec13|SEC13]]|0.418|
|[[:human genes:z:znf655|ZNF655]]|0.417|
|[[:human genes:s:s1pr4|S1PR4]]|0.417|
|[[:human genes:a:ankle2|ANKLE2]]|0.416|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.415|
|[[:human genes:i:incenp|INCENP]]|0.415|
|[[:human genes:n:nol10|NOL10]]|0.414|
|[[:human genes:c:ckap5|CKAP5]]|0.414|
|[[:human genes:o:or10g3|OR10G3]]|0.414|
|[[:human genes:r:rpl6|RPL6]]|0.414|
|[[:human genes:p:pcf11|PCF11]]|0.414|
|[[:human genes:s:stil|STIL]]|0.414|
|[[:human genes:m:med14|MED14]]|0.413|
|[[:human genes:a:aatf|AATF]]|0.413|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.412|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.411|
|[[:human genes:g:gon4l|GON4L]]|0.411|
|[[:human genes:m:myh2|MYH2]]|0.411|
|[[:human genes:s:shpk|SHPK]]|0.411|
|[[:human genes:a:ankle1|ANKLE1]]|0.411|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.41|
|[[:human genes:r:rplp0|RPLP0]]|0.409|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.409|
|[[:human genes:r:rps9|RPS9]]|0.409|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.409|
|[[:human genes:c:cdt1|CDT1]]|0.408|
|[[:human genes:p:psmb2|PSMB2]]|0.408|
|[[:human genes:n:nup160|NUP160]]|0.407|
|[[:human genes:s:srgap2c|SRGAP2C]]|0.406|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.405|
|[[:human genes:e:eif4a3|EIF4A3]]|0.404|
|[[:human genes:m:mcm7|MCM7]]|0.404|
|[[:human genes:n:nbpf16|NBPF16]]|0.403|
|[[:human genes:n:nup43|NUP43]]|0.403|
|[[:human genes:k:kif3c|KIF3C]]|0.403|
|[[:human genes:r:rpl17|RPL17]]|0.402|
|[[:human genes:p:pdcd7|PDCD7]]|0.401|
|[[:human genes:p:psma6|PSMA6]]|0.401|
|[[:human genes:s:slc6a17|SLC6A17]]|0.401|
|[[:human genes:z:zfand5|ZFAND5]]|0.4|
|[[:human genes:l:lad1|LAD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1094
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS19BP1 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>