RPS3A [The Human Chemical-Genetic Interaction Map Project]

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======= RPS3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS3A
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S3A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6189|6189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61247|P61247]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180478|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role during erythropoiesis through regulation of transcription factor DDIT3. {ECO:0000255|HAMAP-Rule:MF_03122}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S3Ae|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA 5-UTR binding|
|cytosolic small ribosomal subunit|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|ribonucleoprotein complex|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|nucleolus|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|intracellular protein transport|
|endoplasmic reticulum|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.18|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.93|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.89|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.77|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.72|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.73|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.8|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.85|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.99|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.03|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.15|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.48|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps5|RPS5]]|0.55|
|[[:human genes:r:rps9|RPS9]]|0.548|
|[[:human genes:r:rps3|RPS3]]|0.545|
|[[:human genes:d:ddx56|DDX56]]|0.537|
|[[:human genes:r:rps12|RPS12]]|0.521|
|[[:human genes:r:rps16|RPS16]]|0.519|
|[[:human genes:c:cdc6|CDC6]]|0.51|
|[[:human genes:r:rps7|RPS7]]|0.502|
|[[:human genes:n:nol10|NOL10]]|0.501|
|[[:human genes:v:vasn|VASN]]|0.499|
|[[:human genes:p:prim1|PRIM1]]|0.493|
|[[:human genes:n:nob1|NOB1]]|0.486|
|[[:human genes:r:rpl35|RPL35]]|0.485|
|[[:human genes:p:pola2|POLA2]]|0.485|
|[[:human genes:g:golga8o|GOLGA8O]]|0.484|
|[[:human genes:b:bysl|BYSL]]|0.483|
|[[:human genes:p:psmb4|PSMB4]]|0.481|
|[[:human genes:t:tfip11|TFIP11]]|0.481|
|[[:human genes:a:adrm1|ADRM1]]|0.478|
|[[:human genes:r:rpl9|RPL9]]|0.477|
|[[:human genes:r:rps2|RPS2]]|0.475|
|[[:human genes:r:rps19|RPS19]]|0.472|
|[[:human genes:u:utp6|UTP6]]|0.472|
|[[:human genes:t:tceb3c|TCEB3C]]|0.47|
|[[:human genes:o:orc6|ORC6]]|0.466|
|[[:human genes:p:psmd3|PSMD3]]|0.461|
|[[:human genes:c:c14orf93|C14orf93]]|0.461|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.458|
|[[:human genes:m:mdm2|MDM2]]|0.457|
|[[:human genes:r:rpl14|RPL14]]|0.457|
|[[:human genes:s:supt6h|SUPT6H]]|0.457|
|[[:human genes:r:rps11|RPS11]]|0.456|
|[[:human genes:r:rps14|RPS14]]|0.454|
|[[:human genes:p:psma7|PSMA7]]|0.453|
|[[:human genes:p:plk4|PLK4]]|0.453|
|[[:human genes:n:nop16|NOP16]]|0.453|
|[[:human genes:t:twistnb|TWISTNB]]|0.452|
|[[:human genes:l:lrr1|LRR1]]|0.449|
|[[:human genes:c:cdc73|CDC73]]|0.449|
|[[:human genes:c:ckap5|CKAP5]]|0.448|
|[[:human genes:t:tspy8|TSPY8]]|0.443|
|[[:human genes:c:cope|COPE]]|0.442|
|[[:human genes:p:psmd11|PSMD11]]|0.439|
|[[:human genes:d:dtl|DTL]]|0.439|
|[[:human genes:t:terf2|TERF2]]|0.438|
|[[:human genes:m:myo1h|MYO1H]]|0.437|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.437|
|[[:human genes:n:nbpf10|NBPF10]]|0.436|
|[[:human genes:c:cdk8|CDK8]]|0.436|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.436|
|[[:human genes:k:kctd17|KCTD17]]|0.435|
|[[:human genes:p:psma6|PSMA6]]|0.434|
|[[:human genes:g:golga6b|GOLGA6B]]|0.433|
|[[:human genes:p:psmb1|PSMB1]]|0.433|
|[[:human genes:r:rnf113a|RNF113A]]|0.431|
|[[:human genes:r:rpl6|RPL6]]|0.431|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.43|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.428|
|[[:human genes:c:cdc45|CDC45]]|0.426|
|[[:human genes:p:pcf11|PCF11]]|0.424|
|[[:human genes:k:krt78|KRT78]]|0.423|
|[[:human genes:t:ticrr|TICRR]]|0.422|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.42|
|[[:human genes:c:cbwd3|CBWD3]]|0.42|
|[[:human genes:r:rps28|RPS28]]|0.42|
|[[:human genes:s:sf3a3|SF3A3]]|0.419|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.419|
|[[:human genes:n:nip7|NIP7]]|0.419|
|[[:human genes:o:orc1|ORC1]]|0.418|
|[[:human genes:n:npipb5|NPIPB5]]|0.418|
|[[:human genes:g:golga6a|GOLGA6A]]|0.418|
|[[:human genes:n:noc4l|NOC4L]]|0.416|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.416|
|[[:human genes:c:ccna2|CCNA2]]|0.415|
|[[:human genes:w:wdr43|WDR43]]|0.415|
|[[:human genes:p:psmb2|PSMB2]]|0.415|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.413|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.411|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.411|
|[[:human genes:s:slc6a17|SLC6A17]]|0.41|
|[[:human genes:a:acsf2|ACSF2]]|0.41|
|[[:human genes:c:cbwd5|CBWD5]]|0.41|
|[[:human genes:y:yy1|YY1]]|0.409|
|[[:human genes:e:eif4a3|EIF4A3]]|0.409|
|[[:human genes:s:supt5h|SUPT5H]]|0.409|
|[[:human genes:c:chd4|CHD4]]|0.409|
|[[:human genes:t:taf1|TAF1]]|0.409|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.405|
|[[:human genes:c:cdca3|CDCA3]]|0.403|
|[[:human genes:n:nol12|NOL12]]|0.403|
|[[:human genes:p:psmc5|PSMC5]]|0.403|
|[[:human genes:d:disp2|DISP2]]|0.402|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.402|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.401|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.401|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.401|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.401|
|[[:human genes:c:clcn6|CLCN6]]|0.4|
|[[:human genes:s:snrpa1|SNRPA1]]|0.4|
|[[:human genes:c:ctage4|CTAGE4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 716/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|25/26|
|breast|30/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|71/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 231
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS3A Expression in NALM6 Cells: 9.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>