RPS4X [The Human Chemical-Genetic Interaction Map Project]

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======= RPS4X =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS4X
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S4 X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6191|6191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62701|P62701]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS4X&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS4X|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/312760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RS4NT|
|Ribosomal S4e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|small ribosomal subunit|
|rRNA binding|
|polysome|
|ribosome|
|cytosolic small ribosomal subunit|
|cytoplasmic ribonucleoprotein granule|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|positive regulation of translation|
|response to ethanol|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|positive regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|response to alcohol|
|RNA catabolic process|
|establishment of protein localization to membrane|
|synapse|
|response to antibiotic|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|response to toxic substance|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|intracellular protein transport|
|response to drug|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.71|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.12|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.77|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.72|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.7|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.74|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.75|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.85|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.92|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.96|
|[[:results:exp453|B02 10μM R08 exp453]]|1.97|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.04|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.11|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|2.28|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.36|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.46|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.443|
|[[:human genes:p:pole|POLE]]|0.44|
|[[:human genes:p:polr2j3|POLR2J3]]|0.436|
|[[:human genes:p:psmd3|PSMD3]]|0.411|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 681/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|24/26|
|bone|26/26|
|breast|30/30|
|central nervous system|48/49|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|16/18|
|liver|18/19|
|lung|70/72|
|lymphocyte|16/16|
|ovary|25/25|
|pancreas|22/22|
|peripheral nervous system|15/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|20/20|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 196
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS4X Expression in NALM6 Cells: 9.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>