RPS6KA5 [The Human Chemical-Genetic Interaction Map Project]

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======= RPS6KA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS6KA5
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S6 kinase A5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9252|9252]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75582|O75582]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS6KA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS6KA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603607|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase C|
|Pkinase Tyr|
|Kdo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H2A-S1 phosphorylation|
|histone H3-S28 phosphorylation|
|histone H2A phosphorylation|
|histone H3-S10 phosphorylation|
|positive regulation of histone phosphorylation|
|histone-serine phosphorylation|
|regulation of histone phosphorylation|
|positive regulation of CREB transcription factor activity|
|histone phosphorylation|
|positive regulation of histone acetylation|
|positive regulation of peptidyl-lysine acetylation|
|positive regulation of protein acetylation|
|epidermal growth factor receptor signaling pathway|
|regulation of histone acetylation|
|regulation of peptidyl-lysine acetylation|
|ERBB signaling pathway|
|regulation of protein acetylation|
|positive regulation of histone modification|
|interleukin-1-mediated signaling pathway|
|positive regulation of chromatin organization|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of histone modification|
|positive regulation of NF-kappaB transcription factor activity|
|peptidyl-serine phosphorylation|
|cellular response to interleukin-1|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|peptidyl-serine modification|
|response to interleukin-1|
|magnesium ion binding|
|innate immune response-activating signal transduction|
|protein kinase activity|
|activation of innate immune response|
|axon guidance|
|positive regulation of DNA-binding transcription factor activity|
|neuron projection guidance|
|negative regulation of cytokine production|
|positive regulation of innate immune response|
|regulation of chromosome organization|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|histone modification|
|axonogenesis|
|covalent chromatin modification|
|axon development|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|inflammatory response|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of response to biotic stimulus|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|activation of immune response|
|neuron projection development|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|chromatin organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of defense response|
|regulation of multi-organism process|
|neuron development|
|cellular component morphogenesis|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|chromosome organization|
|regulation of response to external stimulus|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.88|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.75|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.8|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.8|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.88|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.14|
|[[:results:exp131|L-74142 5μM R03 exp131]]|2.41|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8151
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS6KA5 Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>