RPS8 [The Human Chemical-Genetic Interaction Map Project]

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======= RPS8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS8
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6202|6202]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62241|P62241]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600357|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S8e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|cytosolic small ribosomal subunit|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|ribonucleoprotein complex|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|endoplasmic reticulum|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.23|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.1|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.06|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.01|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.97|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.89|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.84|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.71|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.73|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.73|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.77|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.8|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.05|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.09|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.11|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.15|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|2.43|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.58|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.478|
|[[:human genes:r:rps5|RPS5]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 728/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 161
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS8 Expression in NALM6 Cells: 9.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>