RPSA [The Human Chemical-Genetic Interaction Map Project]

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======= RPSA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPSA
  * **<color #00a2e8>Official Name</color>**: ribosomal protein SA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3921|3921]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08865|P08865]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPSA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPSA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/150370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|laminin receptor activity|
|ribosomal small subunit assembly|
|laminin binding|
|cytosolic small ribosomal subunit|
|ribosome binding|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|cytoplasmic translation|
|virus receptor activity|
|viral entry into host cell|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|entry into host cell|
|entry into host|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|interaction with host|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|viral life cycle|
|mRNA catabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|cellular macromolecule catabolic process|
|cell adhesion|
|biological adhesion|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-3.15|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.93|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.45|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.21|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.2|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.18|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.18|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.11|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.11|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.1|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.98|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.91|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.84|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.84|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.83|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.83|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.82|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.74|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.71|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.71|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.72|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.84|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.85|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.89|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.97|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.03|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.04|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.13|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.15|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|2.16|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.33|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.33|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.45|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.61|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.62|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.63|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.69|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdc73|CDC73]]|0.509|
|[[:human genes:v:vasn|VASN]]|0.505|
|[[:human genes:p:psmd1|PSMD1]]|0.499|
|[[:human genes:c:c14orf93|C14orf93]]|0.48|
|[[:human genes:l:lrr1|LRR1]]|0.474|
|[[:human genes:p:psma6|PSMA6]]|0.474|
|[[:human genes:n:nupl1|NUPL1]]|0.47|
|[[:human genes:a:akirin2|AKIRIN2]]|0.469|
|[[:human genes:s:scaf1|SCAF1]]|0.464|
|[[:human genes:p:psmd11|PSMD11]]|0.464|
|[[:human genes:a:aqr|AQR]]|0.463|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.46|
|[[:human genes:r:rps9|RPS9]]|0.46|
|[[:human genes:o:ogfr|OGFR]]|0.456|
|[[:human genes:m:mt1e|MT1E]]|0.453|
|[[:human genes:h:hap1|HAP1]]|0.451|
|[[:human genes:d:dtl|DTL]]|0.449|
|[[:human genes:k:kctd17|KCTD17]]|0.447|
|[[:human genes:p:psmc1|PSMC1]]|0.446|
|[[:human genes:n:nup205|NUP205]]|0.445|
|[[:human genes:g:golga8o|GOLGA8O]]|0.443|
|[[:human genes:n:nup160|NUP160]]|0.443|
|[[:human genes:p:psmb4|PSMB4]]|0.442|
|[[:human genes:c:cope|COPE]]|0.441|
|[[:human genes:c:cnot1|CNOT1]]|0.441|
|[[:human genes:d:ddtl|DDTL]]|0.44|
|[[:human genes:o:or11h6|OR11H6]]|0.439|
|[[:human genes:s:snrpa1|SNRPA1]]|0.439|
|[[:human genes:p:psmd3|PSMD3]]|0.438|
|[[:human genes:s:smg7|SMG7]]|0.432|
|[[:human genes:a:ahctf1|AHCTF1]]|0.432|
|[[:human genes:c:cbwd3|CBWD3]]|0.431|
|[[:human genes:t:twistnb|TWISTNB]]|0.431|
|[[:human genes:z:zfand5|ZFAND5]]|0.43|
|[[:human genes:t:tfip11|TFIP11]]|0.429|
|[[:human genes:a:aaas|AAAS]]|0.426|
|[[:human genes:t:tceb3c|TCEB3C]]|0.426|
|[[:human genes:i:ints5|INTS5]]|0.426|
|[[:human genes:r:rps2|RPS2]]|0.425|
|[[:human genes:a:adrm1|ADRM1]]|0.425|
|[[:human genes:a:acsf2|ACSF2]]|0.423|
|[[:human genes:c:cbwd5|CBWD5]]|0.423|
|[[:human genes:s:supt5h|SUPT5H]]|0.422|
|[[:human genes:c:cdc6|CDC6]]|0.422|
|[[:human genes:o:orc1|ORC1]]|0.421|
|[[:human genes:d:dido1|DIDO1]]|0.421|
|[[:human genes:g:gar1|GAR1]]|0.42|
|[[:human genes:c:cdca3|CDCA3]]|0.42|
|[[:human genes:c:cwc22|CWC22]]|0.42|
|[[:human genes:p:pole|POLE]]|0.419|
|[[:human genes:c:ccna2|CCNA2]]|0.419|
|[[:human genes:p:pwp2|PWP2]]|0.419|
|[[:human genes:n:nup133|NUP133]]|0.418|
|[[:human genes:p:paf1|PAF1]]|0.418|
|[[:human genes:p:psmc3|PSMC3]]|0.416|
|[[:human genes:s:slc4a1|SLC4A1]]|0.416|
|[[:human genes:r:rrn3|RRN3]]|0.416|
|[[:human genes:n:nup54|NUP54]]|0.414|
|[[:human genes:c:cbwd6|CBWD6]]|0.413|
|[[:human genes:r:rad21|RAD21]]|0.412|
|[[:human genes:r:rps12|RPS12]]|0.412|
|[[:human genes:d:disp2|DISP2]]|0.412|
|[[:human genes:p:psma7|PSMA7]]|0.412|
|[[:human genes:g:gon4l|GON4L]]|0.411|
|[[:human genes:r:rad51|RAD51]]|0.411|
|[[:human genes:z:znf106|ZNF106]]|0.41|
|[[:human genes:f:fam86b2|FAM86B2]]|0.41|
|[[:human genes:n:npipb5|NPIPB5]]|0.409|
|[[:human genes:d:dnm2|DNM2]]|0.408|
|[[:human genes:s:s1pr4|S1PR4]]|0.408|
|[[:human genes:p:plk1|PLK1]]|0.408|
|[[:human genes:p:psmd2|PSMD2]]|0.407|
|[[:human genes:t:thoc1|THOC1]]|0.405|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.405|
|[[:human genes:k:kif3c|KIF3C]]|0.405|
|[[:human genes:a:atxn1|ATXN1]]|0.404|
|[[:human genes:r:rbbp5|RBBP5]]|0.404|
|[[:human genes:s:ssh2|SSH2]]|0.403|
|[[:human genes:p:psmc2|PSMC2]]|0.403|
|[[:human genes:p:polr2f|POLR2F]]|0.403|
|[[:human genes:c:chd4|CHD4]]|0.402|
|[[:human genes:p:psmc6|PSMC6]]|0.402|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.402|
|[[:human genes:f:fbxo5|FBXO5]]|0.401|
|[[:human genes:s:smg5|SMG5]]|0.4|
|[[:human genes:s:smg1|SMG1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 212/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|9/26|
|breast|9/33|
|central nervous system|19/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|7/20|
|lung|30/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|7/24|
|peripheral nervous system|7/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 604
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPSA Expression in NALM6 Cells: 9.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>