RRM2 [The Human Chemical-Genetic Interaction Map Project]

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======= RRM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRM2
  * **<color #00a2e8>Official Name</color>**: ribonucleotide reductase regulatory subunit M2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6241|6241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31350|P31350]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribonuc red sm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonucleoside-diphosphate reductase complex|
|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|
|ferric iron binding|
|deoxyribonucleotide biosynthetic process|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|nucleobase-containing small molecule interconversion|
|protein heterotetramerization|
|deoxyribonucleotide metabolic process|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|protein heterooligomerization|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|protein tetramerization|
|DNA replication|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|negative regulation of cell cycle process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|protein complex oligomerization|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|carbohydrate derivative biosynthetic process|
|mitotic cell cycle|
|regulation of cell cycle process|
|protein homodimerization activity|
|organophosphate metabolic process|
|oxidation-reduction process|
|cell cycle process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|organic cyclic compound biosynthetic process|
|cell cycle|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-3.2|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.67|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.35|
|[[:results:exp539|42°C R08 exp539]]|-2.27|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.91|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.75|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.72|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.7|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.71|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.71|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.72|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.75|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.77|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.83|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.83|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.84|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.85|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.92|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.93|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.94|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.05|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.06|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.08|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.15|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.15|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.23|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.23|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.28|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.32|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.53|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.57|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|4.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt5h|SUPT5H]]|0.447|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.431|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.428|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.427|
|[[:human genes:r:rpl7a|RPL7A]]|0.425|
|[[:human genes:s:slc6a17|SLC6A17]]|0.42|
|[[:human genes:c:cdc6|CDC6]]|0.413|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.413|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.412|
|[[:human genes:t:ticrr|TICRR]]|0.405|
|[[:human genes:p:psmd7|PSMD7]]|0.405|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.404|
|[[:human genes:t:tceb3c|TCEB3C]]|0.402|
|[[:human genes:i:ik|IK]]|0.401|
|[[:human genes:c:copg1|COPG1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 891
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRM2 Expression in NALM6 Cells: 8.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>