RRP7A [The Human Chemical-Genetic Interaction Map Project]

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======= RRP7A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRP7A
  * **<color #00a2e8>Official Name</color>**: ribosomal RNA processing 7 homolog A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27341|27341]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3A4|Q9Y3A4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRP7A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRP7A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619449|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRP7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CURI complex|
|UTP-C complex|
|ribosomal small subunit assembly|
|blastocyst formation|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|blastocyst development|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|in utero embryonic development|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|organelle assembly|
|cellular protein-containing complex assembly|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.21|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.15|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.71|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.72|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.73|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.77|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.11|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.17|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.612|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.594|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.592|
|[[:human genes:p:psmb2|PSMB2]]|0.585|
|[[:human genes:p:polr2j3|POLR2J3]]|0.584|
|[[:human genes:p:psmb4|PSMB4]]|0.564|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.556|
|[[:human genes:p:psma6|PSMA6]]|0.538|
|[[:human genes:r:rpl35|RPL35]]|0.534|
|[[:human genes:c:ccna2|CCNA2]]|0.529|
|[[:human genes:p:psmd2|PSMD2]]|0.523|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.521|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.513|
|[[:human genes:p:pola1|POLA1]]|0.512|
|[[:human genes:c:chd4|CHD4]]|0.511|
|[[:human genes:a:aatf|AATF]]|0.511|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.507|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.506|
|[[:human genes:e:eif4a3|EIF4A3]]|0.506|
|[[:human genes:c:copg1|COPG1]]|0.504|
|[[:human genes:n:npipb5|NPIPB5]]|0.502|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.501|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.499|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.499|
|[[:human genes:s:slc6a17|SLC6A17]]|0.498|
|[[:human genes:c:col2a1|COL2A1]]|0.497|
|[[:human genes:v:vps28|VPS28]]|0.495|
|[[:human genes:r:rps2|RPS2]]|0.495|
|[[:human genes:u:upf1|UPF1]]|0.494|
|[[:human genes:s:slc38a7|SLC38A7]]|0.494|
|[[:human genes:c:c14orf93|C14orf93]]|0.493|
|[[:human genes:s:slc4a1|SLC4A1]]|0.493|
|[[:human genes:c:cdc45|CDC45]]|0.492|
|[[:human genes:u:utp3|UTP3]]|0.49|
|[[:human genes:s:supt5h|SUPT5H]]|0.49|
|[[:human genes:p:polr2d|POLR2D]]|0.49|
|[[:human genes:t:tsg101|TSG101]]|0.49|
|[[:human genes:a:aqr|AQR]]|0.487|
|[[:human genes:d:dtl|DTL]]|0.484|
|[[:human genes:r:rps5|RPS5]]|0.482|
|[[:human genes:c:cbwd3|CBWD3]]|0.482|
|[[:human genes:t:tyms|TYMS]]|0.482|
|[[:human genes:i:ik|IK]]|0.481|
|[[:human genes:i:incenp|INCENP]]|0.48|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.479|
|[[:human genes:e:exosc6|EXOSC6]]|0.478|
|[[:human genes:p:psmd14|PSMD14]]|0.478|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.477|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.476|
|[[:human genes:n:nup160|NUP160]]|0.475|
|[[:human genes:r:rps12|RPS12]]|0.475|
|[[:human genes:p:psmc2|PSMC2]]|0.474|
|[[:human genes:n:nup98|NUP98]]|0.473|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.473|
|[[:human genes:l:lad1|LAD1]]|0.472|
|[[:human genes:c:cbwd5|CBWD5]]|0.472|
|[[:human genes:r:rps19|RPS19]]|0.472|
|[[:human genes:p:pole|POLE]]|0.471|
|[[:human genes:t:tspy8|TSPY8]]|0.467|
|[[:human genes:t:tspy1|TSPY1]]|0.467|
|[[:human genes:k:krt2|KRT2]]|0.467|
|[[:human genes:r:rps10|RPS10]]|0.466|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.466|
|[[:human genes:b:bysl|BYSL]]|0.465|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.465|
|[[:human genes:v:vasn|VASN]]|0.465|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.462|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.462|
|[[:human genes:f:fam25b|FAM25B]]|0.462|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.461|
|[[:human genes:l:lrr1|LRR1]]|0.461|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.461|
|[[:human genes:t:timeless|TIMELESS]]|0.461|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.46|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.459|
|[[:human genes:k:krt78|KRT78]]|0.458|
|[[:human genes:a:acsf2|ACSF2]]|0.458|
|[[:human genes:t:tuba8|TUBA8]]|0.457|
|[[:human genes:t:tspy2|TSPY2]]|0.457|
|[[:human genes:b:brd2|BRD2]]|0.457|
|[[:human genes:i:ints5|INTS5]]|0.457|
|[[:human genes:m:mtch2|MTCH2]]|0.456|
|[[:human genes:o:orc1|ORC1]]|0.456|
|[[:human genes:r:rpl9|RPL9]]|0.455|
|[[:human genes:c:chaf1a|CHAF1A]]|0.454|
|[[:human genes:w:wdr75|WDR75]]|0.453|
|[[:human genes:g:golga8j|GOLGA8J]]|0.452|
|[[:human genes:e:exosc9|EXOSC9]]|0.452|
|[[:human genes:p:polr2l|POLR2L]]|0.452|
|[[:human genes:p:polr2a|POLR2A]]|0.45|
|[[:human genes:k:kpnb1|KPNB1]]|0.45|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.449|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.448|
|[[:human genes:d:ddtl|DDTL]]|0.448|
|[[:human genes:m:mpp3|MPP3]]|0.446|
|[[:human genes:n:nfatc4|NFATC4]]|0.446|
|[[:human genes:k:kctd17|KCTD17]]|0.446|
|[[:human genes:p:psmb1|PSMB1]]|0.446|
|[[:human genes:h:hivep3|HIVEP3]]|0.443|
|[[:human genes:p:pigs|PIGS]]|0.443|
|[[:human genes:c:ctage4|CTAGE4]]|0.443|
|[[:human genes:u:utp20|UTP20]]|0.442|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.441|
|[[:human genes:r:rad51|RAD51]]|0.44|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.44|
|[[:human genes:r:rps7|RPS7]]|0.44|
|[[:human genes:p:psmc6|PSMC6]]|0.438|
|[[:human genes:x:xab2|XAB2]]|0.438|
|[[:human genes:t:twistnb|TWISTNB]]|0.436|
|[[:human genes:f:fam231c|FAM231C]]|0.435|
|[[:human genes:f:fam231a|FAM231A]]|0.435|
|[[:human genes:r:rrp12|RRP12]]|0.434|
|[[:human genes:t:tinf2|TINF2]]|0.434|
|[[:human genes:p:pan2|PAN2]]|0.434|
|[[:human genes:c:cactin|CACTIN]]|0.434|
|[[:human genes:k:kif3c|KIF3C]]|0.433|
|[[:human genes:a:akt1s1|AKT1S1]]|0.433|
|[[:human genes:p:pwp2|PWP2]]|0.433|
|[[:human genes:t:tonsl|TONSL]]|0.433|
|[[:human genes:w:wdr43|WDR43]]|0.432|
|[[:human genes:c:cbwd6|CBWD6]]|0.432|
|[[:human genes:s:snip1|SNIP1]]|0.432|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.432|
|[[:human genes:p:prim1|PRIM1]]|0.431|
|[[:human genes:c:cln6|CLN6]]|0.429|
|[[:human genes:p:psmd7|PSMD7]]|0.428|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.428|
|[[:human genes:u:uqcrh|UQCRH]]|0.428|
|[[:human genes:z:zdhhc19|ZDHHC19]]|0.428|
|[[:human genes:r:riok2|RIOK2]]|0.427|
|[[:human genes:r:rnpc3|RNPC3]]|0.427|
|[[:human genes:s:snrpa1|SNRPA1]]|0.426|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.426|
|[[:human genes:l:lipe|LIPE]]|0.426|
|[[:human genes:c:cep192|CEP192]]|0.426|
|[[:human genes:a:aamp|AAMP]]|0.425|
|[[:human genes:p:plrg1|PLRG1]]|0.424|
|[[:human genes:n:nelfcd|NELFCD]]|0.424|
|[[:human genes:r:ranbp2|RANBP2]]|0.424|
|[[:human genes:p:psmc4|PSMC4]]|0.423|
|[[:human genes:t:ticrr|TICRR]]|0.423|
|[[:human genes:c:c3orf17|C3orf17]]|0.422|
|[[:human genes:f:fcn2|FCN2]]|0.422|
|[[:human genes:a:ankle1|ANKLE1]]|0.421|
|[[:human genes:p:psma7|PSMA7]]|0.421|
|[[:human genes:p:paf1|PAF1]]|0.421|
|[[:human genes:c:cdc6|CDC6]]|0.421|
|[[:human genes:r:rpl6|RPL6]]|0.42|
|[[:human genes:s:spats2|SPATS2]]|0.42|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.42|
|[[:human genes:t:ttc1|TTC1]]|0.419|
|[[:human genes:t:tpx2|TPX2]]|0.418|
|[[:human genes:a:art5|ART5]]|0.418|
|[[:human genes:m:mt1e|MT1E]]|0.418|
|[[:human genes:m:mms22l|MMS22L]]|0.417|
|[[:human genes:c:cope|COPE]]|0.417|
|[[:human genes:t:tmem199|TMEM199]]|0.417|
|[[:human genes:a:ahctf1|AHCTF1]]|0.417|
|[[:human genes:p:psmd6|PSMD6]]|0.416|
|[[:human genes:d:disp2|DISP2]]|0.416|
|[[:human genes:p:polr1a|POLR1A]]|0.415|
|[[:human genes:s:sf3a1|SF3A1]]|0.415|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.415|
|[[:human genes:g:golga8o|GOLGA8O]]|0.413|
|[[:human genes:p:polr2f|POLR2F]]|0.413|
|[[:human genes:n:noc4l|NOC4L]]|0.413|
|[[:human genes:r:rrn3|RRN3]]|0.412|
|[[:human genes:c:chchd3|CHCHD3]]|0.411|
|[[:human genes:n:narfl|NARFL]]|0.411|
|[[:human genes:d:ddx18|DDX18]]|0.411|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.411|
|[[:human genes:n:npipa7|NPIPA7]]|0.41|
|[[:human genes:c:copb2|COPB2]]|0.41|
|[[:human genes:d:dhx38|DHX38]]|0.41|
|[[:human genes:g:golga8k|GOLGA8K]]|0.41|
|[[:human genes:t:tfip11|TFIP11]]|0.41|
|[[:human genes:i:isy1|ISY1]]|0.409|
|[[:human genes:n:npipa8|NPIPA8]]|0.409|
|[[:human genes:e:eftud2|EFTUD2]]|0.409|
|[[:human genes:m:mcoln1|MCOLN1]]|0.409|
|[[:human genes:n:ncl|NCL]]|0.408|
|[[:human genes:d:dock6|DOCK6]]|0.407|
|[[:human genes:n:ngdn|NGDN]]|0.407|
|[[:human genes:m:med17|MED17]]|0.407|
|[[:human genes:t:trappc11|TRAPPC11]]|0.407|
|[[:human genes:c:chmp4b|CHMP4B]]|0.407|
|[[:human genes:p:pno1|PNO1]]|0.407|
|[[:human genes:a:apc2|APC2]]|0.406|
|[[:human genes:c:ccdc116|CCDC116]]|0.406|
|[[:human genes:r:rnf113a|RNF113A]]|0.406|
|[[:human genes:p:psap|PSAP]]|0.406|
|[[:human genes:f:fbl|FBL]]|0.405|
|[[:human genes:t:ttyh1|TTYH1]]|0.405|
|[[:human genes:e:exosc8|EXOSC8]]|0.404|
|[[:human genes:a:ankle2|ANKLE2]]|0.404|
|[[:human genes:s:sec13|SEC13]]|0.404|
|[[:human genes:s:sart1|SART1]]|0.404|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.403|
|[[:human genes:i:iscu|ISCU]]|0.403|
|[[:human genes:c:cdca3|CDCA3]]|0.402|
|[[:human genes:a:atp13a1|ATP13A1]]|0.402|
|[[:human genes:d:dimt1|DIMT1]]|0.402|
|[[:human genes:s:ssh2|SSH2]]|0.402|
|[[:human genes:e:egr2|EGR2]]|0.401|
|[[:human genes:o:osbp|OSBP]]|0.401|
|[[:human genes:m:mul1|MUL1]]|0.401|
|[[:human genes:p:prpf19|PRPF19]]|0.401|
|[[:human genes:t:traip|TRAIP]]|0.401|
|[[:human genes:k:krt5|KRT5]]|0.4|
|[[:human genes:o:orc6|ORC6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 132/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|5/26|
|breast|7/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|3/21|
|liver|1/20|
|lung|20/75|
|lymphocyte|3/16|
|ovary|8/26|
|pancreas|3/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1172
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRP7A Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>