RSAD2 [The Human Chemical-Genetic Interaction Map Project]

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======= RSAD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RSAD2
  * **<color #00a2e8>Official Name</color>**: radical S-adenosyl methionine domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91543|91543]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WXG1|Q8WXG1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RSAD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RSAD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607810|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'- linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)- mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16108059, ECO:0000269|PubMed:16982913, ECO:0000269|PubMed:17686841, ECO:0000269|PubMed:18005719, ECO:0000269|PubMed:19074433}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Radical SAM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of toll-like receptor 7 signaling pathway|
|positive regulation of toll-like receptor 9 signaling pathway|
|regulation of toll-like receptor 7 signaling pathway|
|positive regulation of T-helper 2 cell cytokine production|
|regulation of toll-like receptor 9 signaling pathway|
|regulation of T-helper 2 cell cytokine production|
|positive regulation of type 2 immune response|
|positive regulation of T cell cytokine production|
|positive regulation of toll-like receptor signaling pathway|
|regulation of type 2 immune response|
|regulation of T cell cytokine production|
|CD4-positive, alpha-beta T cell differentiation|
|CD4-positive, alpha-beta T cell activation|
|4 iron, 4 sulfur cluster binding|
|catalytic activity|
|positive regulation of T cell mediated immunity|
|alpha-beta T cell differentiation|
|positive regulation of cytokine production involved in immune response|
|protein self-association|
|negative regulation of viral genome replication|
|alpha-beta T cell activation|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|regulation of toll-like receptor signaling pathway|
|regulation of T cell mediated immunity|
|response to type I interferon|
|negative regulation of viral life cycle|
|lipid droplet|
|regulation of cytokine production involved in immune response|
|regulation of viral genome replication|
|positive regulation of production of molecular mediator of immune response|
|negative regulation of viral process|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|negative regulation of protein secretion|
|positive regulation of leukocyte mediated immunity|
|fibrillar center|
|T cell differentiation|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|regulation of viral life cycle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|mitochondrial outer membrane|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|defense response to virus|
|negative regulation of secretion by cell|
|regulation of viral process|
|regulation of leukocyte mediated immunity|
|negative regulation of multi-organism process|
|positive regulation of immune effector process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of secretion|
|T cell activation|
|lymphocyte differentiation|
|response to virus|
|leukocyte differentiation|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|mitochondrial inner membrane|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|negative regulation of transport|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|hemopoiesis|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|immune system development|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|positive regulation of immune response|
|leukocyte activation|
|endoplasmic reticulum membrane|
|defense response to other organism|
|Golgi apparatus|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|regulation of protein localization|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.76|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8061
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RSAD2 Expression in NALM6 Cells: 0.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>