RSC1A1 [The Human Chemical-Genetic Interaction Map Project]

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======= RSC1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RSC1A1
  * **<color #00a2e8>Official Name</color>**: regulator of solute carriers 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6248|6248]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92681|Q92681]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RSC1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RSC1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601966|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. {ECO:0000269|PubMed:14724758, ECO:0000269|PubMed:16788146, ECO:0000269|PubMed:8836035}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sodium channel inhibitor activity|
|negative regulation of glucose transmembrane transport|
|negative regulation of exocytosis|
|regulation of glucose transmembrane transport|
|negative regulation of transmembrane transport|
|negative regulation of secretion by cell|
|regulation of exocytosis|
|negative regulation of secretion|
|negative regulation of transport|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|regulation of secretion by cell|
|regulation of secretion|
|Golgi apparatus|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.05|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.05|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.03|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.93|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.78|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.7|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.81|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.465|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11639
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RSC1A1 Expression in NALM6 Cells: 3.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>