RSL1D1 [The Human Chemical-Genetic Interaction Map Project]

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======= RSL1D1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RSL1D1
  * **<color #00a2e8>Official Name</color>**: ribosomal L1 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26156|26156]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76021|O76021]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RSL1D1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RSL1D1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615874|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|90S preribosome|
|maturation of LSU-rRNA|
|mRNA 5-UTR binding|
|regulation of cellular senescence|
|regulation of cell aging|
|ribosomal large subunit biogenesis|
|mRNA 3-UTR binding|
|osteoblast differentiation|
|rRNA processing|
|rRNA metabolic process|
|ossification|
|ribosome biogenesis|
|cadherin binding|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|regulation of cellular response to stress|
|nucleolus|
|RNA processing|
|regulation of protein localization|
|RNA binding|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|RNA metabolic process|
|regulation of cell death|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.85|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.76|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.83|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.03|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.12|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.45|
|[[:human genes:s:smg7|SMG7]]|0.426|
|[[:human genes:r:rpl35|RPL35]]|0.42|
|[[:human genes:s:ssh2|SSH2]]|0.415|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.413|
|[[:human genes:z:zfand5|ZFAND5]]|0.41|
|[[:human genes:i:ints6|INTS6]]|0.409|
|[[:human genes:e:eif4a3|EIF4A3]]|0.402|
|[[:human genes:r:rpl38|RPL38]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 706/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|27/28|
|bone|26/26|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|14/16|
|ovary|21/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 842
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RSL1D1 Expression in NALM6 Cells: 7.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>