RTN4IP1 [The Human Chemical-Genetic Interaction Map Project]

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======= RTN4IP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RTN4IP1
  * **<color #00a2e8>Official Name</color>**: reticulon 4 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84816|84816]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WWV3|Q8WWV3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RTN4IP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RTN4IP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610502|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. {ECO:0000250|UniProtKB:Q924D0}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADH zinc N|
|ADH N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidoreductase activity|
|regulation of dendrite development|
|mitochondrial outer membrane|
|regulation of neuron projection development|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|zinc ion binding|
|regulation of nervous system development|
|regulation of cell development|
|oxidation-reduction process|
|mitochondrion|
|generation of neurons|
|neurogenesis|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.71|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.72|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.75|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.78|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.81|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.82|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.84|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.96|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.38|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufc2|NDUFC2]]|0.661|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.65|
|[[:human genes:n:ndufa1|NDUFA1]]|0.639|
|[[:human genes:m:mrps21|MRPS21]]|0.581|
|[[:human genes:n:ndufb5|NDUFB5]]|0.577|
|[[:human genes:n:ndufb11|NDUFB11]]|0.577|
|[[:human genes:n:ndufa3|NDUFA3]]|0.57|
|[[:human genes:n:ndufa11|NDUFA11]]|0.569|
|[[:human genes:n:ndufa2|NDUFA2]]|0.567|
|[[:human genes:n:ndufb9|NDUFB9]]|0.564|
|[[:human genes:g:gfm1|GFM1]]|0.564|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.557|
|[[:human genes:n:ndufs2|NDUFS2]]|0.553|
|[[:human genes:l:lars2|LARS2]]|0.552|
|[[:human genes:m:mrpl45|MRPL45]]|0.55|
|[[:human genes:n:ndufa10|NDUFA10]]|0.55|
|[[:human genes:t:tfb1m|TFB1M]]|0.549|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.545|
|[[:human genes:a:atp5sl|ATP5SL]]|0.544|
|[[:human genes:q:qrsl1|QRSL1]]|0.544|
|[[:human genes:g:grsf1|GRSF1]]|0.541|
|[[:human genes:r:rpusd3|RPUSD3]]|0.54|
|[[:human genes:c:c10orf2|C10orf2]]|0.539|
|[[:human genes:n:ndufs1|NDUFS1]]|0.534|
|[[:human genes:d:dap3|DAP3]]|0.533|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.528|
|[[:human genes:y:yars2|YARS2]]|0.527|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.527|
|[[:human genes:d:dars2|DARS2]]|0.523|
|[[:human genes:a:acad9|ACAD9]]|0.522|
|[[:human genes:m:mrp63|MRP63]]|0.519|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.518|
|[[:human genes:c:cars2|CARS2]]|0.512|
|[[:human genes:n:ndufb4|NDUFB4]]|0.511|
|[[:human genes:n:nars2|NARS2]]|0.509|
|[[:human genes:c:c12orf65|C12orf65]]|0.508|
|[[:human genes:n:ndufs5|NDUFS5]]|0.507|
|[[:human genes:m:mrpl21|MRPL21]]|0.506|
|[[:human genes:m:mrpl47|MRPL47]]|0.503|
|[[:human genes:e:ears2|EARS2]]|0.503|
|[[:human genes:m:mars2|MARS2]]|0.502|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.502|
|[[:human genes:n:ndufa13|NDUFA13]]|0.499|
|[[:human genes:n:ndufc1|NDUFC1]]|0.498|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.498|
|[[:human genes:n:nubpl|NUBPL]]|0.498|
|[[:human genes:a:atp5c1|ATP5C1]]|0.495|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.494|
|[[:human genes:w:wbscr16|WBSCR16]]|0.494|
|[[:human genes:r:rars2|RARS2]]|0.493|
|[[:human genes:m:mrpl43|MRPL43]]|0.491|
|[[:human genes:m:mrps16|MRPS16]]|0.489|
|[[:human genes:v:vars2|VARS2]]|0.488|
|[[:human genes:n:ndufs3|NDUFS3]]|0.487|
|[[:human genes:c:cox16|COX16]]|0.486|
|[[:human genes:m:mterfd1|MTERFD1]]|0.486|
|[[:human genes:o:oma1|OMA1]]|0.486|
|[[:human genes:n:ndufb7|NDUFB7]]|0.485|
|[[:human genes:n:ndufa5|NDUFA5]]|0.485|
|[[:human genes:p:pdss1|PDSS1]]|0.484|
|[[:human genes:m:mrps6|MRPS6]]|0.484|
|[[:human genes:c:cox7b|COX7B]]|0.484|
|[[:human genes:n:ndufv1|NDUFV1]]|0.483|
|[[:human genes:m:mto1|MTO1]]|0.483|
|[[:human genes:f:foxred1|FOXRED1]]|0.482|
|[[:human genes:c:c17orf89|C17orf89]]|0.482|
|[[:human genes:n:ndufs7|NDUFS7]]|0.48|
|[[:human genes:n:ndufb6|NDUFB6]]|0.48|
|[[:human genes:e:ecsit|ECSIT]]|0.475|
|[[:human genes:n:ndufb2|NDUFB2]]|0.475|
|[[:human genes:f:ftsj2|FTSJ2]]|0.472|
|[[:human genes:n:ndufb3|NDUFB3]]|0.47|
|[[:human genes:p:pars2|PARS2]]|0.469|
|[[:human genes:p:pet117|PET117]]|0.467|
|[[:human genes:m:mrps26|MRPS26]]|0.466|
|[[:human genes:c:chchd1|CHCHD1]]|0.466|
|[[:human genes:t:tmem261|TMEM261]]|0.465|
|[[:human genes:n:ndufa8|NDUFA8]]|0.465|
|[[:human genes:r:rpusd4|RPUSD4]]|0.465|
|[[:human genes:s:selrc1|SELRC1]]|0.461|
|[[:human genes:b:bcs1l|BCS1L]]|0.458|
|[[:human genes:t:tars2|TARS2]]|0.458|
|[[:human genes:a:aifm1|AIFM1]]|0.458|
|[[:human genes:g:gfm2|GFM2]]|0.457|
|[[:human genes:n:ndufs8|NDUFS8]]|0.456|
|[[:human genes:r:rbfa|RBFA]]|0.455|
|[[:human genes:m:mrps33|MRPS33]]|0.453|
|[[:human genes:t:timm21|TIMM21]]|0.452|
|[[:human genes:f:fastkd2|FASTKD2]]|0.452|
|[[:human genes:c:coa3|COA3]]|0.451|
|[[:human genes:h:hars2|HARS2]]|0.45|
|[[:human genes:p:pet112|PET112]]|0.45|
|[[:human genes:m:mrpl15|MRPL15]]|0.45|
|[[:human genes:m:mrps5|MRPS5]]|0.449|
|[[:human genes:m:mrpl3|MRPL3]]|0.447|
|[[:human genes:m:mrps25|MRPS25]]|0.446|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.446|
|[[:human genes:m:mtif2|MTIF2]]|0.445|
|[[:human genes:t:tufm|TUFM]]|0.444|
|[[:human genes:n:nfu1|NFU1]]|0.444|
|[[:human genes:t:tefm|TEFM]]|0.443|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.442|
|[[:human genes:m:mrps14|MRPS14]]|0.44|
|[[:human genes:p:polg2|POLG2]]|0.44|
|[[:human genes:c:coq7|COQ7]]|0.439|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.439|
|[[:human genes:s:sars2|SARS2]]|0.438|
|[[:human genes:m:mrpl23|MRPL23]]|0.438|
|[[:human genes:t:tfam|TFAM]]|0.437|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.435|
|[[:human genes:m:mrps34|MRPS34]]|0.435|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.434|
|[[:human genes:n:ndufb10|NDUFB10]]|0.434|
|[[:human genes:s:slc25a26|SLC25A26]]|0.433|
|[[:human genes:c:cox19|COX19]]|0.432|
|[[:human genes:m:mrps7|MRPS7]]|0.432|
|[[:human genes:f:fastkd5|FASTKD5]]|0.432|
|[[:human genes:m:mrpl1|MRPL1]]|0.431|
|[[:human genes:p:pnpt1|PNPT1]]|0.43|
|[[:human genes:m:mrps27|MRPS27]]|0.43|
|[[:human genes:s:sco2|SCO2]]|0.429|
|[[:human genes:c:coq2|COQ2]]|0.426|
|[[:human genes:a:atp5o|ATP5O]]|0.425|
|[[:human genes:g:gatc|GATC]]|0.424|
|[[:human genes:n:ndufb8|NDUFB8]]|0.424|
|[[:human genes:a:atp5h|ATP5H]]|0.424|
|[[:human genes:c:c1qbp|C1QBP]]|0.423|
|[[:human genes:a:atp5a1|ATP5A1]]|0.423|
|[[:human genes:m:mrps10|MRPS10]]|0.422|
|[[:human genes:m:mrpl53|MRPL53]]|0.422|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.422|
|[[:human genes:m:mtif3|MTIF3]]|0.421|
|[[:human genes:p:ptcd3|PTCD3]]|0.421|
|[[:human genes:a:atp5b|ATP5B]]|0.419|
|[[:human genes:m:mtg2|MTG2]]|0.419|
|[[:human genes:p:polg|POLG]]|0.418|
|[[:human genes:n:ndufa6|NDUFA6]]|0.417|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.417|
|[[:human genes:s:slc25a52|SLC25A52]]|0.415|
|[[:human genes:a:atp5d|ATP5D]]|0.414|
|[[:human genes:m:mrpl44|MRPL44]]|0.414|
|[[:human genes:t:tomm7|TOMM7]]|0.412|
|[[:human genes:a:atp5e|ATP5E]]|0.411|
|[[:human genes:c:cox15|COX15]]|0.411|
|[[:human genes:w:wars2|WARS2]]|0.408|
|[[:human genes:m:mettl17|METTL17]]|0.408|
|[[:human genes:t:trmt10c|TRMT10C]]|0.404|
|[[:human genes:n:ndufa9|NDUFA9]]|0.403|
|[[:human genes:s:slc25a51|SLC25A51]]|0.403|
|[[:human genes:p:polrmt|POLRMT]]|0.403|
|[[:human genes:m:mrpl51|MRPL51]]|0.402|
|[[:human genes:c:clpp|CLPP]]|0.401|
|[[:human genes:s:ssbp1|SSBP1]]|0.401|
|[[:human genes:m:mrpl28|MRPL28]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1895
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RTN4IP1 Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>