RUFY3 [The Human Chemical-Genetic Interaction Map Project]

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======= RUFY3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RUFY3
  * **<color #00a2e8>Official Name</color>**: RUN and FYVE domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22902|22902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L099|Q7L099]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RUFY3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RUFY3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611194|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:25766321}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RUN|
|FYVE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|invadopodium|
|regulation of establishment of cell polarity|
|regulation of establishment or maintenance of cell polarity|
|positive regulation of axon extension|
|negative regulation of axonogenesis|
|filopodium|
|endomembrane system|
|positive regulation of axonogenesis|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of extent of cell growth|
|growth cone|
|perikaryon|
|positive regulation of intracellular protein transport|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|lamellipodium|
|negative regulation of cell projection organization|
|regulation of cell size|
|regulation of axonogenesis|
|positive regulation of intracellular transport|
|negative regulation of neuron differentiation|
|regulation of intracellular protein transport|
|actin filament organization|
|positive regulation of growth|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of intracellular transport|
|positive regulation of neuron differentiation|
|neuronal cell body|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of cell growth|
|dendrite|
|positive regulation of protein transport|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|cell junction|
|positive regulation of locomotion|
|actin filament-based process|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.09|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.78|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.04|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.05|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.17|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.24|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.31|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.38|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13452
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RUFY3 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>