S100A1 [The Human Chemical-Genetic Interaction Map Project]

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======= S100A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: S100A1
  * **<color #00a2e8>Official Name</color>**: S100 calcium binding protein A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6271|6271]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23297|P23297]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=S100A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20S100A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176940|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity (PubMed:22399290). {ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:23351007}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
|S 100|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of voltage-gated calcium channel activity|
|S100 protein binding|
|positive regulation of nitric-oxide synthase activity|
|positive regulation of monooxygenase activity|
|M band|
|regulation of voltage-gated calcium channel activity|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of sprouting angiogenesis|
|substantia nigra development|
|sarcoplasmic reticulum|
|regulation of nitric-oxide synthase activity|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|calcium-dependent protein binding|
|neural nucleus development|
|positive regulation of cation channel activity|
|regulation of sprouting angiogenesis|
|positive regulation of calcium ion transmembrane transport|
|ATPase binding|
|midbrain development|
|regulation of calcium ion transmembrane transporter activity|
|regulation of oxidoreductase activity|
|toll-like receptor signaling pathway|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|positive regulation of calcium ion transport|
|pattern recognition receptor signaling pathway|
|Z disc|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|positive regulation of angiogenesis|
|regulation of cation channel activity|
|positive regulation of vasculature development|
|positive regulation of transmembrane transport|
|innate immune response-activating signal transduction|
|regulation of heart contraction|
|regulation of calcium ion transport|
|activation of innate immune response|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of angiogenesis|
|regulation of blood circulation|
|regulation of vasculature development|
|neuron projection|
|regulation of cation transmembrane transport|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of metal ion transport|
|regulation of innate immune response|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|regulation of system process|
|immune response-regulating signaling pathway|
|protein-containing complex|
|positive regulation of response to external stimulus|
|activation of immune response|
|regulation of ion transport|
|calcium ion binding|
|brain development|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|protein homodimerization activity|
|central nervous system development|
|positive regulation of transport|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of immune system process|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.73|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.76|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.1|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15672
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='S100A1 Expression in NALM6 Cells: 1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>