S100B [The Human Chemical-Genetic Interaction Map Project]

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======= S100B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: S100B
  * **<color #00a2e8>Official Name</color>**: S100 calcium binding protein B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6285|6285]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04271|P04271]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=S100B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20S100B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. {ECO:0000269|PubMed:20351179, ECO:0000269|PubMed:22399290}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|S 100|
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of skeletal muscle cell differentiation|
|response to methylmercury|
|RAGE receptor binding|
|negative regulation of skeletal muscle tissue development|
|S100 protein binding|
|positive regulation of myelination|
|regulation of skeletal muscle cell differentiation|
|regulation of myelination|
|tau protein binding|
|long-term synaptic potentiation|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of skeletal muscle tissue development|
|negative regulation of muscle tissue development|
|astrocyte differentiation|
|regulation of neuronal synaptic plasticity|
|calcium-dependent protein binding|
|positive regulation of nervous system process|
|ruffle|
|memory|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of nervous system process|
|response to glucocorticoid|
|positive regulation of synaptic transmission|
|regulation of cell shape|
|response to corticosteroid|
|glial cell differentiation|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to hypoxia|
|regulation of synaptic plasticity|
|cellular response to decreased oxygen levels|
|gliogenesis|
|cellular response to oxygen levels|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|learning or memory|
|cognition|
|response to steroid hormone|
|response to hypoxia|
|response to decreased oxygen levels|
|axonogenesis|
|neuronal cell body|
|response to oxygen levels|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell part morphogenesis|
|positive regulation of nervous system development|
|cell morphogenesis involved in differentiation|
|behavior|
|regulation of system process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|neuron projection development|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|calcium ion binding|
|cell morphogenesis|
|innate immune response|
|neuron development|
|cellular component morphogenesis|
|zinc ion binding|
|response to lipid|
|protein homodimerization activity|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|negative regulation of developmental process|
|defense response to other organism|
|central nervous system development|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.83|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.71|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5441
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='S100B Expression in NALM6 Cells: -1.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>