SACM1L [The Human Chemical-Genetic Interaction Map Project]

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======= SACM1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SACM1L
  * **<color #00a2e8>Official Name</color>**: SAC1 like phosphatidylinositide phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22908|22908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NTJ5|Q9NTJ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SACM1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SACM1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606569|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syja N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol bisphosphate phosphatase activity|
|phosphatidylinositol phosphate 4-phosphatase activity|
|phosphatidylinositol-4-phosphate phosphatase activity|
|phosphatidylinositol-3-phosphatase activity|
|phosphatidylinositol dephosphorylation|
|AMPA glutamate receptor complex|
|phospholipid dephosphorylation|
|phosphatase activity|
|integral component of endoplasmic reticulum membrane|
|phosphatidylinositol biosynthetic process|
|phosphatidylinositol metabolic process|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|dephosphorylation|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|Golgi membrane|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|Golgi apparatus|
|endoplasmic reticulum|
|lipid metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.08|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.02|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 476/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|19/28|
|blood|20/28|
|bone|14/26|
|breast|23/33|
|central nervous system|33/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|12/16|
|kidney|16/21|
|liver|11/20|
|lung|53/75|
|lymphocyte|11/16|
|ovary|19/26|
|pancreas|21/24|
|peripheral nervous system|10/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1444
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SACM1L Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>