SAFB [The Human Chemical-Genetic Interaction Map Project]

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======= SAFB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAFB
  * **<color #00a2e8>Official Name</color>**: scaffold attachment factor B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6294|6294]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15424|Q15424]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAFB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAFB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602895|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|SAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular estrogen receptor signaling pathway|
|intracellular steroid hormone receptor signaling pathway|
|double-stranded DNA binding|
|steroid hormone mediated signaling pathway|
|regulation of mRNA processing|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cellular response to steroid hormone stimulus|
|hormone metabolic process|
|response to steroid hormone|
|regulation of mRNA metabolic process|
|chromatin binding|
|sequence-specific DNA binding|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|regulation of growth|
|chromatin organization|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|chromosome organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|RNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.43|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.42|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.31|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.22|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.13|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.12|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.11|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.03|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.01|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.96|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.92|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.91|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.85|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.79|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.78|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.7|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.7|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.93|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.02|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.52|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2371
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAFB Expression in NALM6 Cells: 7.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>