SAP130 [The Human Chemical-Genetic Interaction Map Project]

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======= SAP130 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAP130
  * **<color #00a2e8>Official Name</color>**: Sin3A associated protein 130
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79595|79595]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0E3|Q9H0E3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAP130&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAP130|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609697|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Sin3-type complex|
|nuclear speck|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.48|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.42|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.34|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.33|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.22|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.14|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.03|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.03|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.01|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.96|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.95|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.89|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.88|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.85|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.85|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.85|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.8|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.79|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.77|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.75|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.73|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.72|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.71|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.71|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.71|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.78|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.88|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.92|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.01|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.37|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.43|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.8|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ing1|ING1]]|0.727|
|[[:human genes:b:brms1|BRMS1]]|0.628|
|[[:human genes:s:sin3a|SIN3A]]|0.571|
|[[:human genes:s:suds3|SUDS3]]|0.517|
|[[:human genes:i:itpk1|ITPK1]]|0.468|
|[[:human genes:a:arid4b|ARID4B]]|0.468|
|[[:human genes:b:brd1|BRD1]]|0.45|
|[[:human genes:u:ube2q1|UBE2Q1]]|0.448|
|[[:human genes:r:rbm26|RBM26]]|0.443|
|[[:human genes:p:pds5b|PDS5B]]|0.434|
|[[:human genes:t:tspyl1|TSPYL1]]|0.43|
|[[:human genes:s:spen|SPEN]]|0.422|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.409|
|[[:human genes:f:fam204a|FAM204A]]|0.405|
|[[:human genes:f:fam60a|FAM60A]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5959
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAP130 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>