SAV1 [The Human Chemical-Genetic Interaction Map Project]

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======= SAV1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAV1
  * **<color #00a2e8>Official Name</color>**: salvador family WW domain containing protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60485|60485]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4B6|Q9H4B6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAV1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAV1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cardiac muscle cell proliferation|
|lung epithelial cell differentiation|
|intestinal epithelial cell differentiation|
|lung cell differentiation|
|negative regulation of cardiac muscle tissue growth|
|negative regulation of heart growth|
|hippo signaling|
|regulation of stem cell population maintenance|
|lung epithelium development|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|regulation of cardiac muscle cell proliferation|
|ventricular septum morphogenesis|
|negative regulation of striated muscle tissue development|
|molecular adaptor activity|
|negative regulation of muscle organ development|
|negative regulation of muscle tissue development|
|regulation of cardiac muscle tissue growth|
|positive regulation of fat cell differentiation|
|regulation of heart growth|
|hair follicle development|
|ventricular septum development|
|skin epidermis development|
|cardiac septum morphogenesis|
|molting cycle process|
|hair cycle process|
|regulation of cardiac muscle tissue development|
|hair cycle|
|molting cycle|
|regulation of organ growth|
|columnar/cuboidal epithelial cell differentiation|
|negative regulation of developmental growth|
|cardiac septum development|
|regulation of fat cell differentiation|
|negative regulation of epithelial cell proliferation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|digestive tract development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|digestive system development|
|lung development|
|cardiac chamber development|
|respiratory tube development|
|protein stabilization|
|respiratory system development|
|negative regulation of growth|
|heart morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|keratinocyte differentiation|
|regulation of protein stability|
|epidermal cell differentiation|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|skin development|
|epidermis development|
|regulation of DNA-binding transcription factor activity|
|heart development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|positive regulation of cell death|
|tube development|
|circulatory system development|
|apoptotic process|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|programmed cell death|
|identical protein binding|
|cell death|
|epithelium development|
|negative regulation of multicellular organismal process|
|positive regulation of developmental process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAV1 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>