SCARB1 [The Human Chemical-Genetic Interaction Map Project]

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======= SCARB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCARB1
  * **<color #00a2e8>Official Name</color>**: scavenger receptor class B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=949|949]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WTV0|Q8WTV0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCARB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCARB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218). {ECO:0000269|PubMed:12016218, ECO:0000269|PubMed:12519372, ECO:0000269|PubMed:16020694, ECO:0000269|PubMed:21226579, ECO:0000269|PubMed:26965621}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD36|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|high-density lipoprotein particle receptor activity|
|lipopolysaccharide transport|
|regulation of phosphatidylcholine catabolic process|
|detection of lipopolysaccharide|
|apolipoprotein A-I binding|
|lipopolysaccharide receptor activity|
|sterol import|
|cholesterol import|
|regulation of phospholipid catabolic process|
|recognition of apoptotic cell|
|positive regulation of cholesterol storage|
|androgen biosynthetic process|
|high-density lipoprotein particle clearance|
|high-density lipoprotein particle binding|
|detection of molecule of bacterial origin|
|positive regulation of triglyceride biosynthetic process|
|sterol catabolic process|
|cholesterol catabolic process|
|adhesion of symbiont to host|
|regulation of cholesterol storage|
|1-phosphatidylinositol binding|
|low-density lipoprotein particle binding|
|apolipoprotein binding|
|vitamin transmembrane transport|
|reverse cholesterol transport|
|regulation of triglyceride biosynthetic process|
|high-density lipoprotein particle remodeling|
|detection of external biotic stimulus|
|positive regulation of triglyceride metabolic process|
|positive regulation of lipid storage|
|positive regulation of nitric-oxide synthase activity|
|endothelial cell proliferation|
|detection of biotic stimulus|
|microvillus membrane|
|cholesterol efflux|
|low-density lipoprotein particle clearance|
|androgen metabolic process|
|positive regulation of monooxygenase activity|
|steroid catabolic process|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|blood vessel endothelial cell migration|
|intestinal absorption|
|lipopolysaccharide-mediated signaling pathway|
|acylglycerol homeostasis|
|lipopolysaccharide binding|
|triglyceride homeostasis|
|regulation of triglyceride metabolic process|
|apoptotic cell clearance|
|transporter activity|
|plasma lipoprotein particle clearance|
|vitamin transport|
|regulation of nitric-oxide synthase activity|
|plasma lipoprotein particle organization|
|regulation of lipid storage|
|steroid hormone biosynthetic process|
|protein-lipid complex subunit organization|
|scavenger receptor activity|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|cholesterol transport|
|regulation of lipid catabolic process|
|alcohol catabolic process|
|phosphatidylserine binding|
|hormone biosynthetic process|
|endothelial cell migration|
|sterol transport|
|endocytic vesicle membrane|
|carbohydrate derivative transport|
|regulation of plasma lipoprotein particle levels|
|digestive system process|
|caveola|
|organic hydroxy compound catabolic process|
|virus receptor activity|
|positive regulation of lipid biosynthetic process|
|cholesterol homeostasis|
|sterol homeostasis|
|amyloid-beta binding|
|positive regulation of lipid localization|
|epithelial cell migration|
|regulation of phospholipid metabolic process|
|epithelial cell proliferation|
|epithelium migration|
|phospholipid transport|
|tissue migration|
|viral entry into host cell|
|regulation of oxidoreductase activity|
|regulation of phagocytosis|
|positive regulation of endothelial cell migration|
|entry into host|
|entry into host cell|
|phagocytosis, recognition|
|digestion|
|cholesterol metabolic process|
|cellular hormone metabolic process|
|organophosphate ester transport|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|organic hydroxy compound transport|
|regulation of lipid localization|
|positive regulation of epithelial cell migration|
|positive regulation of lipid metabolic process|
|interaction with host|
|regulation of endothelial cell migration|
|ameboidal-type cell migration|
|cellular response to lipopolysaccharide|
|regulation of lipid biosynthetic process|
|cellular response to molecule of bacterial origin|
|viral life cycle|
|hormone metabolic process|
|cellular response to biotic stimulus|
|regulation of epithelial cell migration|
|receptor-mediated endocytosis|
|cell recognition|
|steroid metabolic process|
|lipid transport|
|lipid catabolic process|
|lysosomal membrane|
|response to lipopolysaccharide|
|alcohol metabolic process|
|lipid localization|
|response to molecule of bacterial origin|
|phagocytosis|
|extracellular structure organization|
|regulation of lipid metabolic process|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|organic anion transport|
|wound healing|
|organic cyclic compound catabolic process|
|positive regulation of cell migration|
|cellular response to lipid|
|detection of chemical stimulus|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|endocytosis|
|response to wounding|
|lipid biosynthetic process|
|anion transport|
|cell surface|
|import into cell|
|intracellular membrane-bounded organelle|
|response to bacterium|
|detection of stimulus|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|protein homodimerization activity|
|regulation of cell motility|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|chemical homeostasis|
|lipid metabolic process|
|transmembrane transport|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.26|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCARB1 Expression in NALM6 Cells: 7.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>