SCN10A [The Human Chemical-Genetic Interaction Map Project]

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======= SCN10A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCN10A
  * **<color #00a2e8>Official Name</color>**: sodium voltage-gated channel alpha subunit 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6336|6336]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5Y9|Q9Y5Y9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCN10A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCN10A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604427|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {ECO:0000269|PubMed:9839820}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|Na trans assoc|
|PKD channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bundle of His cell action potential|
|bundle of His cell to Purkinje myocyte signaling|
|AV node cell action potential|
|AV node cell to bundle of His cell signaling|
|regulation of atrial cardiac muscle cell membrane depolarization|
|clathrin complex|
|AV node cell to bundle of His cell communication|
|bundle of His cell to Purkinje myocyte communication|
|voltage-gated sodium channel complex|
|voltage-gated sodium channel activity|
|cell-cell signaling involved in cardiac conduction|
|neuronal action potential|
|membrane depolarization during action potential|
|regulation of membrane depolarization|
|voltage-gated ion channel activity|
|cell communication involved in cardiac conduction|
|cardiac muscle cell action potential|
|membrane depolarization|
|transmission of nerve impulse|
|integral component of presynaptic membrane|
|sensory perception of pain|
|regulation of cardiac muscle contraction|
|odontogenesis of dentin-containing tooth|
|sodium ion transmembrane transport|
|regulation of striated muscle contraction|
|cardiac conduction|
|action potential|
|regulation of heart rate|
|odontogenesis|
|ion channel binding|
|multicellular organismal signaling|
|sodium ion transport|
|regulation of muscle contraction|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of blood circulation|
|axon|
|glutamatergic synapse|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|ion homeostasis|
|cation transport|
|ion transmembrane transport|
|animal organ morphogenesis|
|sensory perception|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|homeostatic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.95|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.81|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.73|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15457
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCN10A Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>