SDHB [The Human Chemical-Genetic Interaction Map Project]

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======= SDHB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SDHB
  * **<color #00a2e8>Official Name</color>**: succinate dehydrogenase complex iron sulfur subunit B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6390|6390]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21912|P21912]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SDHB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SDHB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/185470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3 iron, 4 sulfur cluster binding|
|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|
|succinate dehydrogenase (ubiquinone) activity|
|succinate metabolic process|
|ubiquinone binding|
|2 iron, 2 sulfur cluster binding|
|tricarboxylic acid cycle|
|4 iron, 4 sulfur cluster binding|
|electron transfer activity|
|aerobic respiration|
|dicarboxylic acid metabolic process|
|mitochondrial membrane|
|respiratory electron transport chain|
|cellular respiration|
|electron transport chain|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|drug metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.95|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 107/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|12/28|
|bone|1/26|
|breast|15/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|2/20|
|lung|11/75|
|lymphocyte|6/16|
|ovary|2/26|
|pancreas|7/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1197
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SDHB Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>