SEC31A [The Human Chemical-Genetic Interaction Map Project]

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======= SEC31A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC31A
  * **<color #00a2e8>Official Name</color>**: SEC31 homolog A, COPII coat complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22872|22872]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94979|O94979]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC31A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC31A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610257|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec16 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle coat|
|COPII-coated vesicle cargo loading|
|COPII vesicle coat|
|vesicle cargo loading|
|endoplasmic reticulum exit site|
|COPII-coated ER to Golgi transport vesicle|
|ER to Golgi transport vesicle membrane|
|endoplasmic reticulum organization|
|IRE1-mediated unfolded protein response|
|calcium-dependent protein binding|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|localization within membrane|
|vesicle targeting|
|vesicle budding from membrane|
|antigen processing and presentation of peptide antigen via MHC class I|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|response to calcium ion|
|response to unfolded protein|
|establishment of vesicle localization|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|response to topologically incorrect protein|
|antigen processing and presentation of peptide antigen|
|structural molecule activity|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|response to endoplasmic reticulum stress|
|vesicle organization|
|establishment of organelle localization|
|response to metal ion|
|Golgi vesicle transport|
|endomembrane system organization|
|response to inorganic substance|
|organelle localization|
|Golgi membrane|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|membrane organization|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|endoplasmic reticulum|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-3.98|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-3.38|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-3.13|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-3.11|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.99|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.82|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.81|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.64|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.22|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.09|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.98|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.88|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.83|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.81|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.75|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.76|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.83|
|[[:results:exp539|42°C R08 exp539]]|1.87|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.89|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.97|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.98|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.98|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.12|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.18|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.21|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.46|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.56|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.98|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.19|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|3.22|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.41|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|4.24|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.49|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|4.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sec23b|SEC23B]]|0.582|
|[[:human genes:s:sar1a|SAR1A]]|0.553|
|[[:human genes:s:sec16a|SEC16A]]|0.46|
|[[:human genes:t:tmed2|TMED2]]|0.455|
|[[:human genes:u:uso1|USO1]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14561
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC31A Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>