SEC61B [The Human Chemical-Genetic Interaction Map Project]

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======= SEC61B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC61B
  * **<color #00a2e8>Official Name</color>**: SEC61 translocon subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10952|10952]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60468|P60468]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC61B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC61B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609214|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for protein translocation in the endoplasmic reticulum.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec61 beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum Sec complex|
|epidermal growth factor binding|
|posttranslational protein targeting to membrane, translocation|
|Sec61 translocon complex|
|SRP-dependent cotranslational protein targeting to membrane, translocation|
|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|
|posttranslational protein targeting to endoplasmic reticulum membrane|
|retrograde protein transport, ER to cytosol|
|endoplasmic reticulum to cytosol transport|
|ARF guanyl-nucleotide exchange factor activity|
|protein exit from endoplasmic reticulum|
|intracellular protein transmembrane transport|
|protein transmembrane transport|
|ubiquitin-dependent ERAD pathway|
|ERAD pathway|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|response to endoplasmic reticulum stress|
|establishment of protein localization to membrane|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein localization to organelle|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|transmembrane transport|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.72|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.74|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.84|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.89|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sec63|SEC63]]|0.576|
|[[:human genes:a:alg5|ALG5]]|0.489|
|[[:human genes:m:manf|MANF]]|0.46|
|[[:human genes:r:rpn2|RPN2]]|0.431|
|[[:human genes:t:tmed10|TMED10]]|0.424|
|[[:human genes:r:romo1|ROMO1]]|0.412|
|[[:human genes:u:ube2g2|UBE2G2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|4/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|2/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1810
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC61B Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>