Show pageOld revisionsBacklinksFold/unfold allBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ======= SEC61G ======= == Gene Information == * **<color #00a2e8>Official Symbol</color>**: SEC61G * **<color #00a2e8>Official Name</color>**: SEC61 translocon subunit gamma * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23480|23480]] * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60059|P60059]] * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC61G&organism=9606|BioGRID]] * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC61G|Open PubMed]] * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609215|Open OMIM]] == Function Summary == * **<color #00a2e8>Entrez Summary</color>**: N/A * **<color #00a2e8>UniProt Summary</color>**: Necessary for protein translocation in the endoplasmic reticulum. {ECO:0000250}. <button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button> <button type='primary' size='sm' modal='GO_terms'>GO Terms</button> <modal id='Pfam_Domains' size='lg' title='Pfam Domains'> |SecE| </modal> <modal id='GO_terms' size='lg' title='GO Terms'> |P-P-bond-hydrolysis-driven protein transmembrane transporter activity| |protein transmembrane transporter activity| |protein transmembrane transport| |protein targeting to ER| |establishment of protein localization to endoplasmic reticulum| |protein localization to endoplasmic reticulum| |protein targeting| |establishment of protein localization to organelle| |protein localization to organelle| |endoplasmic reticulum membrane| |intracellular protein transport| |transmembrane transport| |protein transport| |intracellular transport| |peptide transport| |amide transport| |cellular protein localization| |cellular macromolecule localization| |establishment of protein localization| |establishment of localization in cell| |nitrogen compound transport| |membrane| </modal> \\ === CRISPR Data === <button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button> <button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button> <button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button> <modal id='Compound_Hit' size='lg' title='Compound Hit'> ^Screen^Score^ |[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.88| |[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.82| |[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.8| |[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.79| |[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.75| |[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.85| |[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.91| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.25| </modal> <modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'> ^Gene^Correlation^ |[[:human genes:h:hspd1|HSPD1]]|0.539| |[[:human genes:r:rnmt|RNMT]]|0.525| |[[:human genes:t:triap1|TRIAP1]]|0.523| |[[:human genes:g:gmppb|GMPPB]]|0.512| |[[:human genes:t:thg1l|THG1L]]|0.502| |[[:human genes:p:pmm2|PMM2]]|0.5| |[[:human genes:n:nae1|NAE1]]|0.498| |[[:human genes:g:gtf3c6|GTF3C6]]|0.492| |[[:human genes:a:apaf1|APAF1]]|0.481| |[[:human genes:a:adsl|ADSL]]|0.474| |[[:human genes:g:gtf3c2|GTF3C2]]|0.459| |[[:human genes:u:uap1|UAP1]]|0.458| |[[:human genes:b:bap1|BAP1]]|0.456| |[[:human genes:p:pik3r4|PIK3R4]]|0.454| |[[:human genes:t:trnt1|TRNT1]]|0.45| |[[:human genes:h:hccs|HCCS]]|0.449| |[[:human genes:r:rptor|RPTOR]]|0.445| |[[:human genes:c:cycs|CYCS]]|0.443| |[[:human genes:a:atp2a2|ATP2A2]]|0.443| |[[:human genes:e:eif4e|EIF4E]]|0.439| |[[:human genes:r:romo1|ROMO1]]|0.438| |[[:human genes:c:csnk2b|CSNK2B]]|0.437| |[[:human genes:v:vrk1|VRK1]]|0.437| |[[:human genes:g:gfpt1|GFPT1]]|0.435| |[[:human genes:d:dad1|DAD1]]|0.434| |[[:human genes:s:spcs2|SPCS2]]|0.433| |[[:human genes:a:atxn10|ATXN10]]|0.433| |[[:human genes:m:meaf6|MEAF6]]|0.432| |[[:human genes:d:dpagt1|DPAGT1]]|0.431| |[[:human genes:u:utp23|UTP23]]|0.428| |[[:human genes:a:aars|AARS]]|0.427| |[[:human genes:e:eny2|ENY2]]|0.426| |[[:human genes:d:dohh|DOHH]]|0.425| |[[:human genes:r:rpp21|RPP21]]|0.423| |[[:human genes:d:dpf2|DPF2]]|0.422| |[[:human genes:s:srp14|SRP14]]|0.422| |[[:human genes:a:alg13|ALG13]]|0.416| |[[:human genes:b:bak1|BAK1]]|0.416| |[[:human genes:a:alg1|ALG1]]|0.416| |[[:human genes:c:ctdnep1|CTDNEP1]]|0.416| |[[:human genes:p:plaa|PLAA]]|0.415| |[[:human genes:g:gtf3c3|GTF3C3]]|0.415| |[[:human genes:r:rtcb|RTCB]]|0.415| |[[:human genes:a:alg5|ALG5]]|0.414| |[[:human genes:r:rpe|RPE]]|0.413| |[[:human genes:g:gtf3c4|GTF3C4]]|0.413| |[[:human genes:c:casp9|CASP9]]|0.412| |[[:human genes:c:chchd4|CHCHD4]]|0.411| |[[:human genes:z:znhit1|ZNHIT1]]|0.41| |[[:human genes:s:ssb|SSB]]|0.41| |[[:human genes:h:haus8|HAUS8]]|0.407| |[[:human genes:v:vezt|VEZT]]|0.406| |[[:human genes:m:mtor|MTOR]]|0.405| |[[:human genes:t:telo2|TELO2]]|0.403| |[[:human genes:p:pisd|PISD]]|0.403| |[[:human genes:r:rpn1|RPN1]]|0.403| |[[:human genes:c:cbfb|CBFB]]|0.401| |[[:human genes:t:tsen54|TSEN54]]|0.401| |[[:human genes:e:eif1ax|EIF1AX]]|0.401| |[[:human genes:p:ppcs|PPCS]]|0.401| |[[:human genes:t:trmt5|TRMT5]]|0.4| </modal> <modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'> Global Fraction of Cell Lines Where Essential: 254/739 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|1/1| |909776.0|0/1| |bile duct|11/28| |blood|10/28| |bone|8/26| |breast|15/33| |central nervous system|17/56| |cervix|2/4| |colorectal|3/17| |esophagus|4/13| |fibroblast|1/1| |gastric|3/16| |kidney|11/21| |liver|11/20| |lung|27/75| |lymphocyte|5/16| |ovary|10/26| |pancreas|1/24| |peripheral nervous system|8/16| |plasma cell|8/15| |prostate|0/1| |skin|2/24| |soft tissue|6/9| |thyroid|0/2| |upper aerodigestive|6/22| |urinary tract|11/29| |uterus|3/5| </modal> == Essentiality in NALM6 == * **<color #00a2e8>Essentiality Rank</color>**: 3961 * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 <button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button> <modal id='Dist_expr' size='lg' title='SEC61G Expression in NALM6 Cells: 5.27'> {{:chemogenomics:nalm6 dist.png?nolink |}} </modal> Last modified: 2025/12/10 20:19by 127.0.0.1