SEC63 [The Human Chemical-Genetic Interaction Map Project]

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======= SEC63 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC63
  * **<color #00a2e8>Official Name</color>**: SEC63 homolog, protein translocation regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11231|11231]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UGP8|Q9UGP8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC63&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC63|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608648|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec63|
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Sec62/Sec63 complex|
|posttranslational protein targeting to membrane, translocation|
|posttranslational protein targeting to endoplasmic reticulum membrane|
|multicellular organism aging|
|intracellular protein transmembrane transport|
|protein transmembrane transport|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|liver development|
|hepaticobiliary system development|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|signaling receptor activity|
|establishment of protein localization to membrane|
|aging|
|protein targeting|
|gland development|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|endoplasmic reticulum|
|transmembrane transport|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.98|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.54|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.46|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.28|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.03|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.89|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.73|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.73|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.73|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.76|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.78|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.78|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.81|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.82|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.85|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.94|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.95|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.97|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.98|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.05|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.24|
|[[:results:exp539|42°C R08 exp539]]|2.33|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.39|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.46|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.69|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.98|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sec61b|SEC61B]]|0.576|
|[[:human genes:s:sec62|SEC62]]|0.565|
|[[:human genes:m:mbtps2|MBTPS2]]|0.552|
|[[:human genes:m:manf|MANF]]|0.541|
|[[:human genes:a:alg6|ALG6]]|0.537|
|[[:human genes:a:alg5|ALG5]]|0.51|
|[[:human genes:a:alg9|ALG9]]|0.498|
|[[:human genes:d:dpm3|DPM3]]|0.492|
|[[:human genes:t:tmed10|TMED10]]|0.489|
|[[:human genes:m:mbtps1|MBTPS1]]|0.486|
|[[:human genes:u:ube2g2|UBE2G2]]|0.478|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.478|
|[[:human genes:c:cbfb|CBFB]]|0.473|
|[[:human genes:d:dnajc3|DNAJC3]]|0.471|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.471|
|[[:human genes:d:dpagt1|DPAGT1]]|0.471|
|[[:human genes:r:romo1|ROMO1]]|0.466|
|[[:human genes:p:plaa|PLAA]]|0.465|
|[[:human genes:u:uba5|UBA5]]|0.464|
|[[:human genes:d:dpm1|DPM1]]|0.46|
|[[:human genes:p:pdap1|PDAP1]]|0.458|
|[[:human genes:d:dohh|DOHH]]|0.454|
|[[:human genes:u:uap1|UAP1]]|0.45|
|[[:human genes:a:alg1|ALG1]]|0.45|
|[[:human genes:a:alg8|ALG8]]|0.441|
|[[:human genes:m:mpdu1|MPDU1]]|0.44|
|[[:human genes:s:srd5a3|SRD5A3]]|0.437|
|[[:human genes:b:bap1|BAP1]]|0.436|
|[[:human genes:s:srp14|SRP14]]|0.432|
|[[:human genes:u:ube2j1|UBE2J1]]|0.431|
|[[:human genes:p:pmm2|PMM2]]|0.429|
|[[:human genes:d:dhrsx|DHRSX]]|0.427|
|[[:human genes:d:dad1|DAD1]]|0.426|
|[[:human genes:t:triap1|TRIAP1]]|0.426|
|[[:human genes:a:atp2a2|ATP2A2]]|0.425|
|[[:human genes:s:stt3a|STT3A]]|0.423|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.423|
|[[:human genes:g:gfpt1|GFPT1]]|0.417|
|[[:human genes:d:dolk|DOLK]]|0.414|
|[[:human genes:u:ufc1|UFC1]]|0.413|
|[[:human genes:a:alg3|ALG3]]|0.411|
|[[:human genes:i:id3|ID3]]|0.411|
|[[:human genes:o:opa1|OPA1]]|0.41|
|[[:human genes:o:ost4|OST4]]|0.408|
|[[:human genes:s:slc33a1|SLC33A1]]|0.405|
|[[:human genes:n:nsd1|NSD1]]|0.404|
|[[:human genes:u:ufm1|UFM1]]|0.403|
|[[:human genes:t:timm13|TIMM13]]|0.403|
|[[:human genes:r:rpn2|RPN2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 37/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|0/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2351
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC63 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>