SEMA4A [The Human Chemical-Genetic Interaction Map Project]

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======= SEMA4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA4A
  * **<color #00a2e8>Official Name</color>**: semaphorin 4A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64218|64218]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3S1|Q9H3S1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607292|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). {ECO:0000250|UniProtKB:Q62178}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sema|
|PSI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of inhibitory synapse assembly|
|positive regulation of excitatory synapse assembly|
|regulation of inhibitory synapse assembly|
|T-helper 1 cell differentiation|
|regulation of excitatory synapse assembly|
|neuropilin binding|
|T-helper 1 type immune response|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|chemorepellent activity|
|alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell activation involved in immune response|
|negative regulation of axon guidance|
|regulation of axon extension involved in axon guidance|
|T cell differentiation involved in immune response|
|CD4-positive, alpha-beta T cell differentiation|
|semaphorin-plexin signaling pathway|
|CD4-positive, alpha-beta T cell activation|
|negative regulation of axon extension|
|regulation of axon guidance|
|negative chemotaxis|
|alpha-beta T cell differentiation|
|neural crest cell migration|
|negative regulation of chemotaxis|
|alpha-beta T cell activation|
|T cell activation involved in immune response|
|positive regulation of synapse assembly|
|negative regulation of axonogenesis|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of developmental growth|
|regulation of synapse assembly|
|lymphocyte activation involved in immune response|
|regulation of extent of cell growth|
|negative regulation of vasculature development|
|T cell differentiation|
|regulation of cell shape|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of endothelial cell migration|
|ameboidal-type cell migration|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of chemotaxis|
|regulation of synapse organization|
|regulation of epithelial cell migration|
|mesenchyme development|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|T cell activation|
|lymphocyte differentiation|
|negative regulation of growth|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of developmental growth|
|leukocyte differentiation|
|negative regulation of cell development|
|negative regulation of response to external stimulus|
|axonogenesis|
|regulation of cellular component size|
|lymphocyte activation|
|blood vessel morphogenesis|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|vasculature development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.471|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5235
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA4A Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>