SENP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SENP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SENP1
  * **<color #00a2e8>Official Name</color>**: SUMO specific peptidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29843|29843]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0U3|Q9P0U3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SENP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SENP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612157|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:25406032}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C48|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SUMO-specific isopeptidase activity|
|regulation of definitive erythrocyte differentiation|
|protein desumoylation|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of erythrocyte differentiation|
|negative regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of proteasomal protein catabolic process|
|protein sumoylation|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|endopeptidase activity|
|negative regulation of cellular protein catabolic process|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of protein catabolic process|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of endopeptidase activity|
|regulation of proteasomal protein catabolic process|
|positive regulation of peptidase activity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of myeloid cell differentiation|
|nuclear membrane|
|regulation of cysteine-type endopeptidase activity|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|apoptotic signaling pathway|
|protein modification by small protein removal|
|negative regulation of catabolic process|
|peptidyl-lysine modification|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|regulation of protein catabolic process|
|focal adhesion|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of hemopoiesis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-3.49|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.51|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.09|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.05|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.04|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.02|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.99|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.76|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.7|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.7|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.71|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.84|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.92|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.93|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.09|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.11|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.16|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.27|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|3.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15432
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SENP1 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>