SERP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SERP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERP1
  * **<color #00a2e8>Official Name</color>**: stress associated endoplasmic reticulum protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27230|27230]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6X1|Q9Y6X1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617674|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RAMP4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of growth hormone secretion|
|regulation of growth hormone secretion|
|multicellular organism aging|
|ribosome|
|positive regulation of organ growth|
|cytoplasmic microtubule|
|IRE1-mediated unfolded protein response|
|positive regulation of insulin secretion|
|muscle organ morphogenesis|
|post-embryonic development|
|plasma membrane organization|
|regulation of organ growth|
|positive regulation of peptide hormone secretion|
|endoplasmic reticulum unfolded protein response|
|glucose metabolic process|
|positive regulation of translation|
|cellular response to unfolded protein|
|positive regulation of hormone secretion|
|cellular response to topologically incorrect protein|
|positive regulation of cellular amide metabolic process|
|hexose metabolic process|
|response to unfolded protein|
|positive regulation of developmental growth|
|regulation of insulin secretion|
|response to topologically incorrect protein|
|monosaccharide metabolic process|
|regulation of peptide hormone secretion|
|protein glycosylation|
|response to endoplasmic reticulum stress|
|macromolecule glycosylation|
|positive regulation of growth|
|glycosylation|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|aging|
|positive regulation of peptide secretion|
|muscle organ development|
|glycoprotein biosynthetic process|
|regulation of developmental growth|
|regulation of translation|
|glycoprotein metabolic process|
|positive regulation of secretion by cell|
|regulation of cellular amide metabolic process|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|carbohydrate metabolic process|
|muscle structure development|
|regulation of peptide secretion|
|skeletal system development|
|posttranscriptional regulation of gene expression|
|regulation of hormone levels|
|carbohydrate derivative biosynthetic process|
|regulation of growth|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|membrane organization|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|positive regulation of transport|
|endoplasmic reticulum|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|protein transport|
|peptide transport|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.91|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15769
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERP1 Expression in NALM6 Cells: 7.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>