SF3A3 [The Human Chemical-Genetic Interaction Map Project]

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======= SF3A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SF3A3
  * **<color #00a2e8>Official Name</color>**: splicing factor 3a subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10946|10946]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12874|Q12874]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SF3A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SF3A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605596|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SF3a60 bindingd|
|DUF3449|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type prespliceosome assembly|
|mRNA 3-splice site recognition|
|U2 snRNP|
|mRNA splice site selection|
|U2-type precatalytic spliceosome|
|spliceosomal complex assembly|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|zinc ion binding|
|cellular protein-containing complex assembly|
|RNA processing|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.9|
|[[:results:exp539|42°C R08 exp539]]|-1.82|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.77|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.7|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.71|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.72|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.76|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.79|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.82|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.84|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.89|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.14|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dtl|DTL]]|0.542|
|[[:human genes:v:vasn|VASN]]|0.527|
|[[:human genes:a:akirin2|AKIRIN2]]|0.503|
|[[:human genes:t:tceb3c|TCEB3C]]|0.497|
|[[:human genes:c:chd4|CHD4]]|0.495|
|[[:human genes:n:narfl|NARFL]]|0.495|
|[[:human genes:p:paf1|PAF1]]|0.493|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.489|
|[[:human genes:r:rpl35|RPL35]]|0.485|
|[[:human genes:p:polr2a|POLR2A]]|0.483|
|[[:human genes:w:wdr75|WDR75]]|0.482|
|[[:human genes:o:orc6|ORC6]]|0.481|
|[[:human genes:p:psmb2|PSMB2]]|0.476|
|[[:human genes:m:mt1e|MT1E]]|0.476|
|[[:human genes:m:mylk3|MYLK3]]|0.475|
|[[:human genes:i:ints6|INTS6]]|0.469|
|[[:human genes:s:supt6h|SUPT6H]]|0.468|
|[[:human genes:p:prim1|PRIM1]]|0.468|
|[[:human genes:g:gid4|GID4]]|0.468|
|[[:human genes:s:sf3a2|SF3A2]]|0.467|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.466|
|[[:human genes:k:kctd17|KCTD17]]|0.466|
|[[:human genes:p:psmb4|PSMB4]]|0.461|
|[[:human genes:r:rps2|RPS2]]|0.461|
|[[:human genes:o:orc1|ORC1]]|0.46|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.459|
|[[:human genes:c:copg1|COPG1]]|0.459|
|[[:human genes:n:nbpf10|NBPF10]]|0.458|
|[[:human genes:l:lrr1|LRR1]]|0.457|
|[[:human genes:t:ticrr|TICRR]]|0.457|
|[[:human genes:s:snrnp70|SNRNP70]]|0.457|
|[[:human genes:n:npipb5|NPIPB5]]|0.455|
|[[:human genes:r:rrp12|RRP12]]|0.453|
|[[:human genes:n:nol10|NOL10]]|0.452|
|[[:human genes:b:bysl|BYSL]]|0.451|
|[[:human genes:b:brd2|BRD2]]|0.451|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.45|
|[[:human genes:c:cln6|CLN6]]|0.448|
|[[:human genes:u:utp20|UTP20]]|0.448|
|[[:human genes:n:nufip2|NUFIP2]]|0.447|
|[[:human genes:p:pan3|PAN3]]|0.447|
|[[:human genes:r:rbm39|RBM39]]|0.446|
|[[:human genes:r:rps12|RPS12]]|0.445|
|[[:human genes:d:dimt1|DIMT1]]|0.444|
|[[:human genes:c:cdc6|CDC6]]|0.443|
|[[:human genes:e:exd1|EXD1]]|0.443|
|[[:human genes:e:eif4a3|EIF4A3]]|0.443|
|[[:human genes:c:c14orf93|C14orf93]]|0.442|
|[[:human genes:t:tsg101|TSG101]]|0.442|
|[[:human genes:c:copb1|COPB1]]|0.442|
|[[:human genes:c:cdc73|CDC73]]|0.441|
|[[:human genes:z:znf106|ZNF106]]|0.44|
|[[:human genes:p:ppm1d|PPM1D]]|0.44|
|[[:human genes:c:cep192|CEP192]]|0.44|
|[[:human genes:c:cgb2|CGB2]]|0.44|
|[[:human genes:r:rnf113a|RNF113A]]|0.439|
|[[:human genes:r:rps5|RPS5]]|0.435|
|[[:human genes:p:psma6|PSMA6]]|0.435|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.432|
|[[:human genes:g:golga6a|GOLGA6A]]|0.432|
|[[:human genes:p:polr1a|POLR1A]]|0.431|
|[[:human genes:i:ints5|INTS5]]|0.431|
|[[:human genes:p:psmd11|PSMD11]]|0.431|
|[[:human genes:p:psmb1|PSMB1]]|0.431|
|[[:human genes:c:cbwd3|CBWD3]]|0.429|
|[[:human genes:s:sec13|SEC13]]|0.429|
|[[:human genes:n:nop16|NOP16]]|0.429|
|[[:human genes:r:rpl14|RPL14]]|0.428|
|[[:human genes:d:ddtl|DDTL]]|0.427|
|[[:human genes:p:psma7|PSMA7]]|0.426|
|[[:human genes:r:rrp15|RRP15]]|0.426|
|[[:human genes:t:tfip11|TFIP11]]|0.426|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.425|
|[[:human genes:c:cbwd6|CBWD6]]|0.425|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.425|
|[[:human genes:t:terf2|TERF2]]|0.425|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.425|
|[[:human genes:o:osbp|OSBP]]|0.424|
|[[:human genes:s:slc6a17|SLC6A17]]|0.424|
|[[:human genes:c:copa|COPA]]|0.424|
|[[:human genes:s:supt5h|SUPT5H]]|0.424|
|[[:human genes:c:cdt1|CDT1]]|0.423|
|[[:human genes:c:ckap5|CKAP5]]|0.423|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.422|
|[[:human genes:c:ctage4|CTAGE4]]|0.421|
|[[:human genes:p:psmd7|PSMD7]]|0.421|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.42|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.42|
|[[:human genes:u:ubap1|UBAP1]]|0.42|
|[[:human genes:r:rps3a|RPS3A]]|0.419|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.419|
|[[:human genes:c:cbwd5|CBWD5]]|0.419|
|[[:human genes:r:rps19|RPS19]]|0.418|
|[[:human genes:r:rffl|RFFL]]|0.417|
|[[:human genes:m:mfsd12|MFSD12]]|0.417|
|[[:human genes:s:sf3a1|SF3A1]]|0.416|
|[[:human genes:n:nup160|NUP160]]|0.415|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.414|
|[[:human genes:r:riok2|RIOK2]]|0.412|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.412|
|[[:human genes:p:pola2|POLA2]]|0.412|
|[[:human genes:n:napa|NAPA]]|0.411|
|[[:human genes:g:gnb3|GNB3]]|0.411|
|[[:human genes:r:rpl6|RPL6]]|0.41|
|[[:human genes:t:twistnb|TWISTNB]]|0.408|
|[[:human genes:p:psmd3|PSMD3]]|0.408|
|[[:human genes:a:ankle2|ANKLE2]]|0.408|
|[[:human genes:c:chaf1a|CHAF1A]]|0.407|
|[[:human genes:t:tfrc|TFRC]]|0.407|
|[[:human genes:c:cdca3|CDCA3]]|0.407|
|[[:human genes:o:or10g3|OR10G3]]|0.407|
|[[:human genes:r:rfxank|RFXANK]]|0.407|
|[[:human genes:p:pcf11|PCF11]]|0.407|
|[[:human genes:a:arcn1|ARCN1]]|0.407|
|[[:human genes:a:atxn1|ATXN1]]|0.407|
|[[:human genes:r:rrn3|RRN3]]|0.406|
|[[:human genes:n:nol12|NOL12]]|0.406|
|[[:human genes:i:ints8|INTS8]]|0.406|
|[[:human genes:r:rps3|RPS3]]|0.405|
|[[:human genes:s:slc4a1|SLC4A1]]|0.405|
|[[:human genes:i:iscu|ISCU]]|0.404|
|[[:human genes:d:dhx38|DHX38]]|0.404|
|[[:human genes:p:psmd1|PSMD1]]|0.404|
|[[:human genes:r:rbbp5|RBBP5]]|0.404|
|[[:human genes:n:ncl|NCL]]|0.403|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.403|
|[[:human genes:e:esf1|ESF1]]|0.402|
|[[:human genes:c:ctr9|CTR9]]|0.402|
|[[:human genes:s:sf3b1|SF3B1]]|0.402|
|[[:human genes:c:cactin|CACTIN]]|0.402|
|[[:human genes:s:ssh2|SSH2]]|0.402|
|[[:human genes:t:tspy1|TSPY1]]|0.402|
|[[:human genes:i:isy1|ISY1]]|0.402|
|[[:human genes:p:psmc2|PSMC2]]|0.401|
|[[:human genes:p:prpf8|PRPF8]]|0.401|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.401|
|[[:human genes:z:znf655|ZNF655]]|0.4|
|[[:human genes:c:cacna1a|CACNA1A]]|0.4|
|[[:human genes:z:znf830|ZNF830]]|0.4|
|[[:human genes:s:sap30bp|SAP30BP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 675/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|20/26|
|breast|32/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|18/21|
|liver|17/20|
|lung|67/75|
|lymphocyte|16/16|
|ovary|22/26|
|pancreas|23/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 218
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SF3A3 Expression in NALM6 Cells: 7.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>