SF3B2 [The Human Chemical-Genetic Interaction Map Project]

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======= SF3B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SF3B2
  * **<color #00a2e8>Official Name</color>**: splicing factor 3b subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10992|10992]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13435|Q13435]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SF3B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SF3B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605591|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAP|
|PSP|
|DUF382|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2 snRNP|
|U12-type spliceosomal complex|
|U2-type precatalytic spliceosome|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.94|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.92|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.91|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.9|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.72|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.72|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.73|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.74|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.86|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.91|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.94|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.99|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.08|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.489|
|[[:human genes:i:ints5|INTS5]]|0.484|
|[[:human genes:p:psmb4|PSMB4]]|0.454|
|[[:human genes:c:ckap5|CKAP5]]|0.437|
|[[:human genes:s:supt5h|SUPT5H]]|0.436|
|[[:human genes:c:cdc73|CDC73]]|0.43|
|[[:human genes:p:paf1|PAF1]]|0.428|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.425|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.42|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.42|
|[[:human genes:b:brd2|BRD2]]|0.419|
|[[:human genes:t:tceb3c|TCEB3C]]|0.419|
|[[:human genes:s:snrpa1|SNRPA1]]|0.418|
|[[:human genes:s:sf3a2|SF3A2]]|0.414|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.412|
|[[:human genes:i:iscu|ISCU]]|0.409|
|[[:human genes:d:dnm2|DNM2]]|0.409|
|[[:human genes:c:chd4|CHD4]]|0.409|
|[[:human genes:n:nup160|NUP160]]|0.403|
|[[:human genes:s:snrpb|SNRPB]]|0.402|
|[[:human genes:p:phf5a|PHF5A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 650/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|24/28|
|bone|26/26|
|breast|30/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|17/21|
|liver|18/20|
|lung|64/75|
|lymphocyte|14/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 64
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SF3B2 Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>