SFR1 [The Human Chemical-Genetic Interaction Map Project]

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======= SFR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFR1
  * **<color #00a2e8>Official Name</color>**: SWI5 dependent homologous recombination repair protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=119392|119392]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86XK3|Q86XK3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616527|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mei5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Swi5-Sfr1 complex|
|cellular response to estrogen stimulus|
|nuclear receptor transcription coactivator activity|
|response to estrogen|
|double-strand break repair via homologous recombination|
|recombinational repair|
|double-strand break repair|
|DNA recombination|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.66|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.28|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.23|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.04|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.97|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mad2l2|MAD2L2]]|0.478|
|[[:human genes:s:spidr|SPIDR]]|0.458|
|[[:human genes:s:swsap1|SWSAP1]]|0.449|
|[[:human genes:m:mcm8|MCM8]]|0.449|
|[[:human genes:r:rnf168|RNF168]]|0.426|
|[[:human genes:m:mcm9|MCM9]]|0.425|
|[[:human genes:a:atm|ATM]]|0.424|
|[[:human genes:s:swi5|SWI5]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12222
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFR1 Expression in NALM6 Cells: 4.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>