SFRP2 [The Human Chemical-Genetic Interaction Map Project]

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======= SFRP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFRP2
  * **<color #00a2e8>Official Name</color>**: secreted frizzled related protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6423|6423]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HF1|Q96HF1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFRP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFRP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604157|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fz|
|NTR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of dermatome development|
|negative regulation of planar cell polarity pathway involved in axis elongation|
|regulation of planar cell polarity pathway involved in axis elongation|
|negative regulation of mesodermal cell fate specification|
|sclerotome development|
|regulation of dermatome development|
|negative regulation of mesodermal cell differentiation|
|negative regulation of mesoderm formation|
|Wnt signaling pathway involved in somitogenesis|
|regulation of midbrain dopaminergic neuron differentiation|
|negative regulation of non-canonical Wnt signaling pathway|
|negative regulation of cell fate specification|
|convergent extension involved in axis elongation|
|regulation of mesodermal cell differentiation|
|negative regulation of gastrulation|
|endopeptidase activator activity|
|regulation of mesodermal cell fate specification|
|regulation of mesoderm formation|
|negative regulation of mesoderm development|
|regulation of stem cell division|
|regulation of dopaminergic neuron differentiation|
|cellular response to X-ray|
|regulation of cell fate specification|
|negative regulation of cell fate commitment|
|planar cell polarity pathway involved in neural tube closure|
|hematopoietic stem cell proliferation|
|negative regulation of JUN kinase activity|
|cardiac left ventricle morphogenesis|
|convergent extension|
|regulation of establishment of planar polarity involved in neural tube closure|
|regulation of Wnt signaling pathway, planar cell polarity pathway|
|regulation of mesoderm development|
|post-anal tail morphogenesis|
|regulation of epithelial tube formation|
|positive regulation of cell adhesion mediated by integrin|
|negative regulation of cardiac muscle cell apoptotic process|
|regulation of non-canonical Wnt signaling pathway|
|negative regulation of striated muscle cell apoptotic process|
|negative regulation of embryonic development|
|axis elongation|
|fibronectin binding|
|negative regulation of epithelial to mesenchymal transition|
|branching involved in blood vessel morphogenesis|
|regulation of cell fate commitment|
|response to X-ray|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|receptor ligand activity|
|negative regulation of JNK cascade|
|regulation of cardiac muscle cell apoptotic process|
|regulation of gastrulation|
|Wnt-protein binding|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of muscle cell apoptotic process|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of striated muscle cell apoptotic process|
|chondrocyte development|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|regulation of cell adhesion mediated by integrin|
|collagen fibril organization|
|digestive tract morphogenesis|
|negative regulation of BMP signaling pathway|
|negative regulation of peptidyl-tyrosine phosphorylation|
|stem cell proliferation|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of osteoblast differentiation|
|embryonic digit morphogenesis|
|positive regulation of fat cell differentiation|
|somitogenesis|
|regulation of muscle cell apoptotic process|
|cellular response to ionizing radiation|
|outflow tract morphogenesis|
|cardiac ventricle morphogenesis|
|negative regulation of MAP kinase activity|
|negative regulation of response to DNA damage stimulus|
|somite development|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|chondrocyte differentiation|
|regulation of epithelial to mesenchymal transition|
|positive regulation of ossification|
|regulation of JUN kinase activity|
|regulation of BMP signaling pathway|
|canonical Wnt signaling pathway|
|negative regulation of cysteine-type endopeptidase activity|
|neural tube closure|
|tube closure|
|segmentation|
|negative regulation of intrinsic apoptotic signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|primary neural tube formation|
|negative regulation of extrinsic apoptotic signaling pathway|
|positive regulation of peptidyl-serine phosphorylation|
|negative regulation of developmental growth|
|neural tube formation|
|regulation of establishment of planar polarity|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|developmental growth involved in morphogenesis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of fat cell differentiation|
|embryonic epithelial tube formation|
|negative regulation of epithelial cell proliferation|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of embryonic development|
|branching morphogenesis of an epithelial tube|
|integrin binding|
|digestive tract development|
|epithelial tube formation|
|negative regulation of protein serine/threonine kinase activity|
|non-canonical Wnt signaling pathway|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of peptidyl-serine phosphorylation|
|digestive system development|
|positive regulation of canonical Wnt signaling pathway|
|morphogenesis of embryonic epithelium|
|tube formation|
|negative regulation of cellular response to growth factor stimulus|
|response to ionizing radiation|
|limb morphogenesis|
|appendage morphogenesis|
|regulation of extrinsic apoptotic signaling pathway|
|male sex differentiation|
|morphogenesis of a branching epithelium|
|neural tube development|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of cell growth|
|positive regulation of angiogenesis|
|negative regulation of MAPK cascade|
|regulation of cell division|
|morphogenesis of a branching structure|
|cardiac chamber development|
|cartilage development|
|positive regulation of endopeptidase activity|
|cellular response to radiation|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|limb development|
|appendage development|
|regulation of morphogenesis of an epithelium|
|positive regulation of vasculature development|
|negative regulation of cell growth|
|regulation of JNK cascade|
|regulation of ossification|
|positive regulation of peptidase activity|
|bone development|
|negative regulation of Wnt signaling pathway|
|gonad development|
|response to nutrient|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|regulation of response to DNA damage stimulus|
|mesenchyme development|
|connective tissue development|
|negative regulation of protein kinase activity|
|negative regulation of apoptotic signaling pathway|
|regulation of stress-activated MAPK cascade|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stress-activated protein kinase signaling cascade|
|skeletal system morphogenesis|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|negative regulation of endopeptidase activity|
|negative regulation of kinase activity|
|heart morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of peptidase activity|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|negative regulation of cell migration|
|cellular response to extracellular stimulus|
|sex differentiation|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|regulation of canonical Wnt signaling pathway|
|regulation of angiogenesis|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of developmental growth|
|regionalization|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|extracellular matrix organization|
|regulation of MAP kinase activity|
|negative regulation of proteolysis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|developmental growth|
|growth|
|regulation of apoptotic signaling pathway|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|regulation of cell growth|
|regulation of endopeptidase activity|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|pattern specification process|
|response to radiation|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|blood vessel development|
|skeletal system development|
|regulation of neuron projection development|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|heart development|
|response to extracellular stimulus|
|cell population proliferation|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell death|
|negative regulation of protein metabolic process|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.03|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3213
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFRP2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>