SGK1 [The Human Chemical-Genetic Interaction Map Project]

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======= SGK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGK1
  * **<color #00a2e8>Official Name</color>**: serum/glucocorticoid regulated kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6446|6446]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00141|O00141]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602958|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase C|
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal sodium ion absorption|
|renal sodium ion transport|
|chloride channel regulator activity|
|regulation of gastric acid secretion|
|renal absorption|
|protein serine/threonine/tyrosine kinase activity|
|long-term memory|
|sodium channel regulator activity|
|calcium channel regulator activity|
|regulation of digestive system process|
|potassium channel regulator activity|
|renal system process|
|positive regulation of transporter activity|
|memory|
|sodium ion transport|
|peptidyl-serine phosphorylation|
|regulation of blood pressure|
|peptidyl-serine modification|
|learning or memory|
|regulation of transporter activity|
|cognition|
|protein serine/threonine kinase activity|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|nuclear speck|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|behavior|
|regulation of system process|
|metal ion transport|
|neuron projection development|
|regulation of growth|
|cell morphogenesis|
|cellular response to DNA damage stimulus|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|cation transport|
|regulation of cell migration|
|peptidyl-amino acid modification|
|regulation of cell motility|
|apoptotic process|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|protein phosphorylation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|neuron differentiation|
|programmed cell death|
|cell death|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|ion transport|
|nervous system process|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.76|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12216
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGK1 Expression in NALM6 Cells: 2.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>