SGSH [The Human Chemical-Genetic Interaction Map Project]

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======= SGSH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGSH
  * **<color #00a2e8>Official Name</color>**: N-sulfoglucosamine sulfohydrolase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6448|6448]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51688|P51688]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGSH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGSH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the enzyme sulfamidase; one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with the lysosomal storage disease mucopolysaccaridosis IIIA, also known as Sanfilippo syndrome A, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. [provided by RefSeq, Jun 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes a step in lysosomal heparan sulfate degradation. {ECO:0000269|PubMed:15146460, ECO:0000269|PubMed:24816101, ECO:0000269|PubMed:7493035}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phosphodiest|
|Sulfatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-sulfoglucosamine sulfohydrolase activity|
|heparan sulfate proteoglycan catabolic process|
|proteoglycan catabolic process|
|sulfuric ester hydrolase activity|
|glycoprotein catabolic process|
|heparan sulfate proteoglycan metabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|proteoglycan metabolic process|
|lysosomal lumen|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|carbohydrate derivative catabolic process|
|lysosome|
|glycoprotein metabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.77|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15521
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGSH Expression in NALM6 Cells: 1.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>