SH3BP1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SH3BP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SH3BP1
  * **<color #00a2e8>Official Name</color>**: SH3 domain binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23616|23616]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3L3|Q9Y3L3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SH3BP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SH3BP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617368|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin- plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BAR|
|RhoGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of epithelial cell apical/basal polarity|
|polarized epithelial cell differentiation|
|establishment of apical/basal cell polarity|
|exocyst|
|establishment of monopolar cell polarity|
|semaphorin receptor binding|
|establishment or maintenance of monopolar cell polarity|
|phagocytic cup|
|establishment of epithelial cell polarity|
|semaphorin-plexin signaling pathway|
|cell leading edge|
|morphogenesis of a polarized epithelium|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|regulation of actin filament depolymerization|
|Rac GTPase binding|
|negative regulation of small GTPase mediated signal transduction|
|adherens junction|
|regulation of protein depolymerization|
|regulation of blood vessel endothelial cell migration|
|regulation of protein complex disassembly|
|establishment of cell polarity|
|bicellular tight junction|
|phagocytosis, engulfment|
|SH3 domain binding|
|plasma membrane invagination|
|membrane invagination|
|regulation of endothelial cell migration|
|cell junction assembly|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|establishment or maintenance of cell polarity|
|cell junction organization|
|regulation of epithelial cell migration|
|actin filament organization|
|regulation of actin filament organization|
|GTPase activator activity|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|morphogenesis of an epithelium|
|supramolecular fiber organization|
|regulation of GTPase activity|
|actin cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|endocytosis|
|tissue morphogenesis|
|actin filament-based process|
|import into cell|
|epithelial cell differentiation|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|membrane organization|
|regulation of cell motility|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|tissue development|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.12|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.78|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.84|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.88|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.88|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psma6|PSMA6]]|0.506|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.502|
|[[:human genes:r:rrp7a|RRP7A]]|0.499|
|[[:human genes:d:dtl|DTL]]|0.495|
|[[:human genes:c:chd4|CHD4]]|0.488|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.487|
|[[:human genes:e:exosc3|EXOSC3]]|0.486|
|[[:human genes:t:tceb3c|TCEB3C]]|0.485|
|[[:human genes:a:ankle1|ANKLE1]]|0.485|
|[[:human genes:p:psmb2|PSMB2]]|0.484|
|[[:human genes:m:med14|MED14]]|0.479|
|[[:human genes:s:slc6a17|SLC6A17]]|0.476|
|[[:human genes:p:polr2d|POLR2D]]|0.475|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.473|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.473|
|[[:human genes:c:cdca3|CDCA3]]|0.472|
|[[:human genes:r:rps12|RPS12]]|0.47|
|[[:human genes:k:kctd17|KCTD17]]|0.467|
|[[:human genes:n:napa|NAPA]]|0.465|
|[[:human genes:n:narfl|NARFL]]|0.463|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.463|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.461|
|[[:human genes:c:cactin|CACTIN]]|0.458|
|[[:human genes:z:zfand5|ZFAND5]]|0.457|
|[[:human genes:t:tsg101|TSG101]]|0.457|
|[[:human genes:d:dock6|DOCK6]]|0.455|
|[[:human genes:m:mtch2|MTCH2]]|0.455|
|[[:human genes:r:rbm39|RBM39]]|0.455|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.454|
|[[:human genes:p:polr2j3|POLR2J3]]|0.454|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.454|
|[[:human genes:a:atp1a3|ATP1A3]]|0.454|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.453|
|[[:human genes:s:smg1|SMG1]]|0.452|
|[[:human genes:s:scmh1|SCMH1]]|0.451|
|[[:human genes:p:prpf19|PRPF19]]|0.449|
|[[:human genes:p:pigs|PIGS]]|0.449|
|[[:human genes:p:pold1|POLD1]]|0.448|
|[[:human genes:r:ranbp2|RANBP2]]|0.447|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.446|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.446|
|[[:human genes:s:syt9|SYT9]]|0.446|
|[[:human genes:n:nol10|NOL10]]|0.442|
|[[:human genes:v:vps28|VPS28]]|0.441|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.44|
|[[:human genes:c:copg1|COPG1]]|0.44|
|[[:human genes:f:fam25b|FAM25B]]|0.438|
|[[:human genes:z:znf830|ZNF830]]|0.437|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.437|
|[[:human genes:c:cln6|CLN6]]|0.436|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.436|
|[[:human genes:w:wdr87|WDR87]]|0.435|
|[[:human genes:k:krt2|KRT2]]|0.435|
|[[:human genes:p:psmd3|PSMD3]]|0.435|
|[[:human genes:g:gosr2|GOSR2]]|0.434|
|[[:human genes:c:chmp4b|CHMP4B]]|0.434|
|[[:human genes:d:dhx38|DHX38]]|0.433|
|[[:human genes:a:aqr|AQR]]|0.432|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.432|
|[[:human genes:t:ticrr|TICRR]]|0.432|
|[[:human genes:p:pan2|PAN2]]|0.431|
|[[:human genes:k:krt78|KRT78]]|0.431|
|[[:human genes:c:cdh24|CDH24]]|0.431|
|[[:human genes:r:rpl6|RPL6]]|0.43|
|[[:human genes:e:exosc9|EXOSC9]]|0.428|
|[[:human genes:u:utp3|UTP3]]|0.428|
|[[:human genes:p:polr2a|POLR2A]]|0.426|
|[[:human genes:r:rplp1|RPLP1]]|0.426|
|[[:human genes:p:prim1|PRIM1]]|0.426|
|[[:human genes:a:aatf|AATF]]|0.425|
|[[:human genes:c:col2a1|COL2A1]]|0.425|
|[[:human genes:m:mms22l|MMS22L]]|0.425|
|[[:human genes:a:agap5|AGAP5]]|0.425|
|[[:human genes:m:mfrp|MFRP]]|0.424|
|[[:human genes:d:ddtl|DDTL]]|0.424|
|[[:human genes:m:mbtd1|MBTD1]]|0.424|
|[[:human genes:p:psmc4|PSMC4]]|0.423|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.423|
|[[:human genes:p:prpf8|PRPF8]]|0.423|
|[[:human genes:r:rpl30|RPL30]]|0.423|
|[[:human genes:c:cbwd3|CBWD3]]|0.422|
|[[:human genes:n:nol12|NOL12]]|0.422|
|[[:human genes:t:twistnb|TWISTNB]]|0.422|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.421|
|[[:human genes:s:supt6h|SUPT6H]]|0.421|
|[[:human genes:t:trappc11|TRAPPC11]]|0.421|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.42|
|[[:human genes:v:vps54|VPS54]]|0.42|
|[[:human genes:e:exd1|EXD1]]|0.42|
|[[:human genes:z:znf541|ZNF541]]|0.42|
|[[:human genes:c:copa|COPA]]|0.419|
|[[:human genes:p:psmb1|PSMB1]]|0.419|
|[[:human genes:o:orc1|ORC1]]|0.417|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.417|
|[[:human genes:p:polr2l|POLR2L]]|0.416|
|[[:human genes:c:cacna1a|CACNA1A]]|0.415|
|[[:human genes:a:acbd4|ACBD4]]|0.415|
|[[:human genes:n:nup153|NUP153]]|0.415|
|[[:human genes:g:gramd1a|GRAMD1A]]|0.414|
|[[:human genes:n:nxf1|NXF1]]|0.413|
|[[:human genes:p:plk1|PLK1]]|0.413|
|[[:human genes:o:osbp|OSBP]]|0.413|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.413|
|[[:human genes:g:gprin2|GPRIN2]]|0.413|
|[[:human genes:v:vasn|VASN]]|0.412|
|[[:human genes:p:prss8|PRSS8]]|0.412|
|[[:human genes:a:apc2|APC2]]|0.41|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.41|
|[[:human genes:p:psmd14|PSMD14]]|0.41|
|[[:human genes:n:nfs1|NFS1]]|0.409|
|[[:human genes:p:pole|POLE]]|0.409|
|[[:human genes:x:xab2|XAB2]]|0.409|
|[[:human genes:g:gid4|GID4]]|0.408|
|[[:human genes:m:mt1e|MT1E]]|0.407|
|[[:human genes:l:lrr1|LRR1]]|0.406|
|[[:human genes:a:akirin2|AKIRIN2]]|0.406|
|[[:human genes:p:psmd2|PSMD2]]|0.405|
|[[:human genes:m:myo1h|MYO1H]]|0.405|
|[[:human genes:i:ik|IK]]|0.404|
|[[:human genes:c:chaf1a|CHAF1A]]|0.404|
|[[:human genes:l:loc643669|LOC643669]]|0.403|
|[[:human genes:p:pan3|PAN3]]|0.403|
|[[:human genes:n:nupl1|NUPL1]]|0.403|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.403|
|[[:human genes:u:ubap1|UBAP1]]|0.402|
|[[:human genes:p:psmb4|PSMB4]]|0.402|
|[[:human genes:a:ankle2|ANKLE2]]|0.402|
|[[:human genes:s:slc4a1|SLC4A1]]|0.402|
|[[:human genes:s:snip1|SNIP1]]|0.401|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.401|
|[[:human genes:t:timeless|TIMELESS]]|0.4|
|[[:human genes:e:exosc5|EXOSC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1954
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SH3BP1 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>