SHFM1 [The Human Chemical-Genetic Interaction Map Project]

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======= SHFM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEM1
  * **<color #00a2e8>Official Name</color>**: SEM1 26S proteasome complex subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7979|7979]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"P60896|Q6ZVN7"|"P60896|Q6ZVN7"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHFM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHFM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSS1 SEM1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome regulatory particle, lid subcomplex|
|proteasome assembly|
|double-strand break repair via homologous recombination|
|recombinational repair|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|double-strand break repair|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|DNA recombination|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.31|
|[[:results:exp539|42°C R08 exp539]]|-2.16|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.03|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.99|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.94|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.87|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.87|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.81|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.7|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.77|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.77|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.78|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.79|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.87|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.97|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.98|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.05|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.05|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|2.21|
|[[:results:exp132|Metformin 40μM R03 exp132]]|2.22|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.27|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|2.59|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps28|RPS28]]|0.409|
|[[:human genes:n:nbpf10|NBPF10]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 330/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|19/28|
|blood|13/28|
|bone|10/26|
|breast|16/33|
|central nervous system|32/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|6/21|
|liver|10/20|
|lung|29/75|
|lymphocyte|10/16|
|ovary|12/26|
|pancreas|6/24|
|peripheral nervous system|7/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|9/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2380
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHFM1 Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>