SHQ1 [The Human Chemical-Genetic Interaction Map Project]

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======= SHQ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SHQ1
  * **<color #00a2e8>Official Name</color>**: SHQ1, H/ACA ribonucleoprotein assembly factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55164|55164]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PI26|Q6PI26]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHQ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHQ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. {ECO:0000269|PubMed:19383767}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SHQ1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|box H/ACA snoRNP assembly|
|negative regulation of rRNA processing|
|negative regulation of ribosome biogenesis|
|small nucleolar ribonucleoprotein complex assembly|
|regulation of rRNA processing|
|regulation of ribosome biogenesis|
|positive regulation of telomerase RNA localization to Cajal body|
|regulation of telomerase RNA localization to Cajal body|
|Cajal body|
|unfolded protein binding|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribonucleoprotein complex biogenesis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of cellular component biogenesis|
|negative regulation of RNA metabolic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 527/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|15/28|
|bone|23/26|
|breast|18/33|
|central nervous system|43/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|16/21|
|liver|14/20|
|lung|58/75|
|lymphocyte|13/16|
|ovary|20/26|
|pancreas|19/24|
|peripheral nervous system|12/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|19/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 585
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHQ1 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>