SIDT2 [The Human Chemical-Genetic Interaction Map Project]

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======= SIDT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIDT2
  * **<color #00a2e8>Official Name</color>**: SID1 transmembrane family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51092|51092]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NBJ9|Q8NBJ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIDT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIDT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617551|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:27046251, ECO:0000269|PubMed:27846365, ECO:0000269|PubMed:28277980}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleic acid transmembrane transporter activity|
|RNA transmembrane transporter activity|
|dsRNA transport|
|AP-1 adaptor complex binding|
|AP-2 adaptor complex binding|
|type B pancreatic cell proliferation|
|type B pancreatic cell development|
|type B pancreatic cell differentiation|
|glandular epithelial cell development|
|enteroendocrine cell differentiation|
|endocrine pancreas development|
|glandular epithelial cell differentiation|
|columnar/cuboidal epithelial cell development|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|double-stranded RNA binding|
|pancreas development|
|epithelial cell proliferation|
|columnar/cuboidal epithelial cell differentiation|
|endocrine system development|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|response to carbohydrate|
|regulation of insulin secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|RNA transport|
|nucleic acid transport|
|epithelial cell development|
|establishment of RNA localization|
|regulation of peptide hormone secretion|
|RNA localization|
|nucleobase-containing compound transport|
|RNA catabolic process|
|lysosome|
|regulation of hormone secretion|
|lysosomal membrane|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of protein secretion|
|organic cyclic compound catabolic process|
|regulation of peptide secretion|
|regulation of hormone levels|
|cell population proliferation|
|epithelial cell differentiation|
|regulation of protein transport|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|cellular component morphogenesis|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|regulation of protein localization|
|macromolecule catabolic process|
|chemical homeostasis|
|epithelium development|
|DNA binding|
|response to oxygen-containing compound|
|homeostatic process|
|cell development|
|RNA metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8186
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIDT2 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>