SIPA1L3 [The Human Chemical-Genetic Interaction Map Project]

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======= SIPA1L3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIPA1L3
  * **<color #00a2e8>Official Name</color>**: signal induced proliferation associated 1 like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23094|23094]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60292|O60292]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIPA1L3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIPA1L3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616655|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rap GAP|
|DUF3401|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tricellular tight junction|
|establishment of epithelial cell polarity|
|epithelial cell morphogenesis|
|stress fiber|
|apical part of cell|
|hematopoietic progenitor cell differentiation|
|establishment of cell polarity|
|epithelial cell development|
|establishment or maintenance of cell polarity|
|GTPase activator activity|
|apical plasma membrane|
|regulation of small GTPase mediated signal transduction|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|epithelial cell differentiation|
|cell morphogenesis|
|positive regulation of hydrolase activity|
|cellular component morphogenesis|
|cytoskeleton organization|
|epithelium development|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|extracellular space|
|cell development|
|tissue development|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.95|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4487
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIPA1L3 Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>