SLC10A7 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC10A7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC10A7
  * **<color #00a2e8>Official Name</color>**: solute carrier family 10 member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84068|84068]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q0GE19|Q0GE19]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC10A7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC10A7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611459|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SBF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycoprotein transport|
|Golgi medial cisterna|
|bile acid transmembrane transporter activity|
|bile acid and bile salt transport|
|intrinsic component of plasma membrane|
|symporter activity|
|cis-Golgi network|
|carbohydrate derivative transport|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|sodium ion transport|
|trans-Golgi network|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid localization|
|Golgi vesicle transport|
|monovalent inorganic cation transport|
|organic anion transport|
|anion transport|
|metal ion transport|
|cation transport|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|transmembrane transport|
|ion transport|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-3.47|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.13|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.57|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.55|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.35|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.3|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.1|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.86|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.98|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.09|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.14|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.17|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17564
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC10A7 Expression in NALM6 Cells: 3.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>