SLC23A2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC23A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC23A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 23 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9962|9962]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UGH3|Q9UGH3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC23A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC23A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603791|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Xan ur permease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-ascorbic acid transmembrane transport|
|L-ascorbate:sodium symporter activity|
|sodium-dependent L-ascorbate transmembrane transporter activity|
|nucleobase transmembrane transporter activity|
|transepithelial L-ascorbic acid transport|
|L-ascorbic acid transmembrane transporter activity|
|coenzyme transport|
|nucleobase transport|
|L-ascorbic acid metabolic process|
|vitamin transmembrane transport|
|transepithelial transport|
|basal plasma membrane|
|monosaccharide transmembrane transport|
|carbohydrate transmembrane transport|
|vitamin transport|
|transporter activity|
|cofactor transport|
|carbohydrate transport|
|water-soluble vitamin metabolic process|
|vitamin metabolic process|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|sodium ion transport|
|basolateral plasma membrane|
|monosaccharide metabolic process|
|coenzyme metabolic process|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|apical plasma membrane|
|response to oxidative stress|
|monovalent inorganic cation transport|
|cofactor metabolic process|
|organic anion transport|
|carbohydrate metabolic process|
|anion transport|
|metal ion transport|
|cation transport|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|small molecule metabolic process|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.1|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.87|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.8|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13891
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC23A2 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>