SLC25A10 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A10
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1468|1468]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBX3|Q9UBX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606794|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dicarboxylic acid transmembrane transporter activity|
|oxaloacetate(2-) transmembrane transport|
|thiosulfate transmembrane transporter activity|
|malate transmembrane transporter activity|
|thiosulfate transport|
|oxaloacetate transport|
|oxaloacetate transmembrane transporter activity|
|malate transport|
|malate transmembrane transport|
|sulfide oxidation|
|sulfide oxidation, using sulfide:quinone oxidoreductase|
|succinate transport|
|succinate transmembrane transporter activity|
|succinate transmembrane transport|
|sulfate transmembrane transporter activity|
|phosphate ion transmembrane transport|
|sulfate transmembrane transport|
|sulfate transport|
|phosphate ion transport|
|antiporter activity|
|C4-dicarboxylate transport|
|sulfur compound transport|
|gluconeogenesis|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|drug transmembrane transport|
|dicarboxylic acid transport|
|inorganic anion transmembrane transport|
|glucose metabolic process|
|carbohydrate biosynthetic process|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|drug transport|
|hexose metabolic process|
|inorganic anion transport|
|monosaccharide metabolic process|
|mitochondrial transport|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|sulfur compound metabolic process|
|mitochondrial inner membrane|
|organic anion transport|
|carbohydrate metabolic process|
|anion transport|
|small molecule biosynthetic process|
|inorganic ion transmembrane transport|
|ion transmembrane transport|
|oxidation-reduction process|
|response to drug|
|mitochondrion|
|transmembrane transport|
|ion transport|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16843
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A10 Expression in NALM6 Cells: 3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>