SLC25A19 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A19
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60386|60386]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HC21|Q9HC21]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. {ECO:0000269|PubMed:18280798}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deoxynucleotide transport|
|deoxynucleotide transmembrane transporter activity|
|thiamine pyrophosphate transmembrane transport|
|thiamine pyrophosphate transmembrane transporter activity|
|thiamine transmembrane transporter activity|
|thiamine transmembrane transport|
|thiamine transport|
|thiamine-containing compound metabolic process|
|pyrimidine-containing compound transmembrane transport|
|vitamin transmembrane transport|
|azole transport|
|nucleotide transport|
|organic cation transport|
|integral component of mitochondrial inner membrane|
|vitamin transport|
|sulfur compound transport|
|cofactor transport|
|drug transmembrane transport|
|carbohydrate derivative transport|
|water-soluble vitamin metabolic process|
|pyrimidine-containing compound metabolic process|
|organophosphate ester transport|
|vitamin metabolic process|
|drug transport|
|nucleobase-containing compound transport|
|anion transmembrane transport|
|sulfur compound metabolic process|
|mitochondrial inner membrane|
|organic anion transport|
|drug metabolic process|
|anion transport|
|cation transmembrane transport|
|cation transport|
|ion transmembrane transport|
|response to drug|
|transmembrane transport|
|ion transport|
|small molecule metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.12|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.11|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.76|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.75|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.75|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.83|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.88|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.98|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.11|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.47|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.54|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.55|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.58|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.62|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tpk1|TPK1]]|0.694|
|[[:human genes:d:dld|DLD]]|0.675|
|[[:human genes:t:thg1l|THG1L]]|0.604|
|[[:human genes:s:slc25a26|SLC25A26]]|0.574|
|[[:human genes:r:rfk|RFK]]|0.567|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.555|
|[[:human genes:f:fdx1|FDX1]]|0.554|
|[[:human genes:a:atic|ATIC]]|0.548|
|[[:human genes:a:atxn10|ATXN10]]|0.543|
|[[:human genes:a:adsl|ADSL]]|0.529|
|[[:human genes:e:elac2|ELAC2]]|0.524|
|[[:human genes:v:vezt|VEZT]]|0.523|
|[[:human genes:a:alg1|ALG1]]|0.518|
|[[:human genes:p:pmm2|PMM2]]|0.515|
|[[:human genes:l:lipt1|LIPT1]]|0.513|
|[[:human genes:f:fh|FH]]|0.498|
|[[:human genes:t:trmt5|TRMT5]]|0.497|
|[[:human genes:b:bcs1l|BCS1L]]|0.494|
|[[:human genes:s:srp14|SRP14]]|0.49|
|[[:human genes:g:gmppb|GMPPB]]|0.489|
|[[:human genes:g:gemin8|GEMIN8]]|0.488|
|[[:human genes:l:lipt2|LIPT2]]|0.488|
|[[:human genes:n:ndufb5|NDUFB5]]|0.486|
|[[:human genes:d:dpagt1|DPAGT1]]|0.484|
|[[:human genes:r:rpp21|RPP21]]|0.483|
|[[:human genes:m:mrps2|MRPS2]]|0.476|
|[[:human genes:t:tmem242|TMEM242]]|0.472|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.472|
|[[:human genes:n:ndufb11|NDUFB11]]|0.471|
|[[:human genes:u:uhrf1|UHRF1]]|0.468|
|[[:human genes:n:nfu1|NFU1]]|0.467|
|[[:human genes:l:lias|LIAS]]|0.466|
|[[:human genes:p:ppcs|PPCS]]|0.466|
|[[:human genes:a:atp5j|ATP5J]]|0.465|
|[[:human genes:g:gfpt1|GFPT1]]|0.463|
|[[:human genes:u:uap1|UAP1]]|0.46|
|[[:human genes:t:ten1|TEN1]]|0.459|
|[[:human genes:p:pelo|PELO]]|0.458|
|[[:human genes:p:ppp6c|PPP6C]]|0.457|
|[[:human genes:c:c15orf41|C15orf41]]|0.457|
|[[:human genes:t:tufm|TUFM]]|0.454|
|[[:human genes:u:uba3|UBA3]]|0.45|
|[[:human genes:m:mrpl27|MRPL27]]|0.449|
|[[:human genes:t:triap1|TRIAP1]]|0.449|
|[[:human genes:d:dr1|DR1]]|0.448|
|[[:human genes:t:tti1|TTI1]]|0.447|
|[[:human genes:t:tsen54|TSEN54]]|0.447|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.445|
|[[:human genes:d:dars2|DARS2]]|0.445|
|[[:human genes:m:mrps16|MRPS16]]|0.444|
|[[:human genes:u:urm1|URM1]]|0.444|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.441|
|[[:human genes:s:sars2|SARS2]]|0.441|
|[[:human genes:m:med16|MED16]]|0.44|
|[[:human genes:i:isca2|ISCA2]]|0.44|
|[[:human genes:l:lsm10|LSM10]]|0.439|
|[[:human genes:r:rpia|RPIA]]|0.438|
|[[:human genes:c:cox16|COX16]]|0.438|
|[[:human genes:m:mrps34|MRPS34]]|0.437|
|[[:human genes:m:mrpl21|MRPL21]]|0.436|
|[[:human genes:a:atp5c1|ATP5C1]]|0.434|
|[[:human genes:r:rptor|RPTOR]]|0.434|
|[[:human genes:d:dap3|DAP3]]|0.434|
|[[:human genes:m:mrps9|MRPS9]]|0.433|
|[[:human genes:g:gfm1|GFM1]]|0.432|
|[[:human genes:y:yars2|YARS2]]|0.431|
|[[:human genes:d:dohh|DOHH]]|0.431|
|[[:human genes:d:ddx39a|DDX39A]]|0.43|
|[[:human genes:a:alg13|ALG13]]|0.429|
|[[:human genes:t:tars2|TARS2]]|0.429|
|[[:human genes:g:gemin6|GEMIN6]]|0.428|
|[[:human genes:n:ndufa3|NDUFA3]]|0.427|
|[[:human genes:m:mrps14|MRPS14]]|0.427|
|[[:human genes:m:mrps33|MRPS33]]|0.427|
|[[:human genes:e:elp2|ELP2]]|0.426|
|[[:human genes:c:cox5a|COX5A]]|0.423|
|[[:human genes:i:iba57|IBA57]]|0.423|
|[[:human genes:n:n6amt1|N6AMT1]]|0.421|
|[[:human genes:r:rbfa|RBFA]]|0.421|
|[[:human genes:r:rpusd4|RPUSD4]]|0.42|
|[[:human genes:a:alg2|ALG2]]|0.42|
|[[:human genes:z:zrsr2|ZRSR2]]|0.419|
|[[:human genes:z:zcrb1|ZCRB1]]|0.419|
|[[:human genes:t:telo2|TELO2]]|0.417|
|[[:human genes:k:kdm8|KDM8]]|0.415|
|[[:human genes:c:c17orf89|C17orf89]]|0.414|
|[[:human genes:e:elp3|ELP3]]|0.414|
|[[:human genes:e:eef1e1|EEF1E1]]|0.413|
|[[:human genes:r:rtcb|RTCB]]|0.412|
|[[:human genes:a:atp5b|ATP5B]]|0.412|
|[[:human genes:c:chchd4|CHCHD4]]|0.411|
|[[:human genes:c:cbfb|CBFB]]|0.41|
|[[:human genes:s:sdha|SDHA]]|0.41|
|[[:human genes:n:ndufa1|NDUFA1]]|0.41|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.41|
|[[:human genes:u:utp23|UTP23]]|0.409|
|[[:human genes:m:mrps5|MRPS5]]|0.409|
|[[:human genes:p:ppp4c|PPP4C]]|0.408|
|[[:human genes:g:gemin7|GEMIN7]]|0.406|
|[[:human genes:p:pdap1|PDAP1]]|0.405|
|[[:human genes:m:mrp63|MRP63]]|0.405|
|[[:human genes:r:rft1|RFT1]]|0.405|
|[[:human genes:l:lsm11|LSM11]]|0.405|
|[[:human genes:m:med4|MED4]]|0.404|
|[[:human genes:m:mbtps2|MBTPS2]]|0.403|
|[[:human genes:c:cep57|CEP57]]|0.403|
|[[:human genes:h:hars2|HARS2]]|0.402|
|[[:human genes:w:wdr1|WDR1]]|0.402|
|[[:human genes:t:tbcb|TBCB]]|0.4|
|[[:human genes:g:gnb1l|GNB1L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 957
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A19 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>