SLC25A20 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A20
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=788|788]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43772|O43772]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613698|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acyl carnitine transmembrane transporter activity|
|acyl carnitine transmembrane transport|
|acyl carnitine transport|
|carnitine shuttle|
|quaternary ammonium group transport|
|fatty acid transmembrane transport|
|ammonium transmembrane transport|
|organic cation transport|
|intracellular lipid transport|
|cofactor transport|
|ammonium transport|
|long-chain fatty acid transport|
|fatty acid transport|
|mitochondrial transmembrane transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|monocarboxylic acid transport|
|mitochondrial transport|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid localization|
|in utero embryonic development|
|mitochondrial inner membrane|
|organic anion transport|
|anion transport|
|cation transmembrane transport|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|cation transport|
|ion transmembrane transport|
|embryo development|
|mitochondrion|
|transmembrane transport|
|ion transport|
|intracellular transport|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.61|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.42|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.04|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.97|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.8|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.7|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.84|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.88|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.18|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.19|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.23|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:timm8a|TIMM8A]]|0.43|
|[[:human genes:t:taz|TAZ]]|0.424|
|[[:human genes:r:romo1|ROMO1]]|0.407|
|[[:human genes:c:c4orf29|C4orf29]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6504
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A20 Expression in NALM6 Cells: 4.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>