SLC25A24 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SLC25A24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A24
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 24
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29957|29957]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NUK1|Q6NUK1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608744|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress- induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATP transmembrane transporter activity|
|ATP transport|
|adenine nucleotide transport|
|purine ribonucleotide transport|
|purine nucleotide transport|
|nucleotide transport|
|carbohydrate derivative transport|
|cellular response to calcium ion|
|organophosphate ester transport|
|drug transport|
|response to calcium ion|
|cellular response to metal ion|
|mitochondrial transport|
|cellular response to inorganic substance|
|nucleobase-containing compound transport|
|cellular response to oxidative stress|
|response to metal ion|
|response to oxidative stress|
|mitochondrial inner membrane|
|organic anion transport|
|response to inorganic substance|
|anion transport|
|calcium ion binding|
|response to drug|
|mitochondrion|
|transmembrane transport|
|ion transport|
|regulation of cell death|
|cellular response to stress|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.72|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.82|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13538
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A24 Expression in NALM6 Cells: 3.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>