SLC25A26 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A26
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=115286|115286]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q70HW3|Q70HW3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611037|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the mitochondrial carrier family which includes nuclear-encoded transporters localized on the inner mitochondrial membranes. Members of the family transport important small molecules across the mitochondrial inner membrane. This protein is involved in the transport of S-adenosylmethionine (SAM) into the mitochondria. Mutations in this gene are associated with combined oxidative phosphorylation deficiency 28. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S- adenosylmethionine (SAM) into the mitochondria. {ECO:0000269|PubMed:14674884, ECO:0000269|PubMed:26522469}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|S-adenosyl-L-methionine transmembrane transporter activity|
|S-adenosyl-L-methionine transmembrane transport|
|S-adenosyl-L-methionine transport|
|coenzyme transport|
|sulfur compound transport|
|cofactor transport|
|drug transmembrane transport|
|drug transport|
|mitochondrial inner membrane|
|response to drug|
|mitochondrion|
|transmembrane transport|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.99|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.7|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.71|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.71|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.71|
|[[:results:exp539|42°C R08 exp539]]|1.73|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.73|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.75|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.76|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.77|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.8|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.81|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.91|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.91|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.99|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.02|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.03|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.19|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.23|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.26|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.37|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.738|
|[[:human genes:t:triap1|TRIAP1]]|0.698|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.664|
|[[:human genes:m:mrpl21|MRPL21]]|0.652|
|[[:human genes:p:pmm2|PMM2]]|0.642|
|[[:human genes:m:mrps14|MRPS14]]|0.628|
|[[:human genes:c:cox16|COX16]]|0.627|
|[[:human genes:b:bcs1l|BCS1L]]|0.623|
|[[:human genes:t:thg1l|THG1L]]|0.621|
|[[:human genes:d:dap3|DAP3]]|0.621|
|[[:human genes:r:rpe|RPE]]|0.614|
|[[:human genes:m:mrps34|MRPS34]]|0.612|
|[[:human genes:c:crls1|CRLS1]]|0.612|
|[[:human genes:y:yars2|YARS2]]|0.612|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.611|
|[[:human genes:n:nfu1|NFU1]]|0.606|
|[[:human genes:d:dars2|DARS2]]|0.598|
|[[:human genes:r:rpusd4|RPUSD4]]|0.592|
|[[:human genes:p:pdss1|PDSS1]]|0.582|
|[[:human genes:r:romo1|ROMO1]]|0.581|
|[[:human genes:w:wbscr16|WBSCR16]]|0.581|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.579|
|[[:human genes:m:mrps5|MRPS5]]|0.575|
|[[:human genes:t:tpk1|TPK1]]|0.575|
|[[:human genes:s:slc25a19|SLC25A19]]|0.574|
|[[:human genes:s:sco2|SCO2]]|0.573|
|[[:human genes:m:mrp63|MRP63]]|0.572|
|[[:human genes:t:tufm|TUFM]]|0.572|
|[[:human genes:m:mrpl23|MRPL23]]|0.571|
|[[:human genes:m:mrps16|MRPS16]]|0.568|
|[[:human genes:a:alg1|ALG1]]|0.567|
|[[:human genes:m:mrps6|MRPS6]]|0.567|
|[[:human genes:l:lsm10|LSM10]]|0.565|
|[[:human genes:a:atic|ATIC]]|0.564|
|[[:human genes:s:sars2|SARS2]]|0.563|
|[[:human genes:t:taz|TAZ]]|0.562|
|[[:human genes:d:dnlz|DNLZ]]|0.562|
|[[:human genes:g:gfm1|GFM1]]|0.56|
|[[:human genes:c:c12orf65|C12orf65]]|0.558|
|[[:human genes:v:vars2|VARS2]]|0.557|
|[[:human genes:s:srp14|SRP14]]|0.556|
|[[:human genes:g:glrx5|GLRX5]]|0.555|
|[[:human genes:h:hars2|HARS2]]|0.555|
|[[:human genes:a:atp5b|ATP5B]]|0.554|
|[[:human genes:a:atxn10|ATXN10]]|0.553|
|[[:human genes:m:mrps18a|MRPS18A]]|0.552|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.551|
|[[:human genes:d:dohh|DOHH]]|0.551|
|[[:human genes:v:vezt|VEZT]]|0.549|
|[[:human genes:a:atp5c1|ATP5C1]]|0.549|
|[[:human genes:r:rbfa|RBFA]]|0.548|
|[[:human genes:s:selrc1|SELRC1]]|0.547|
|[[:human genes:u:uhrf1|UHRF1]]|0.545|
|[[:human genes:d:dhps|DHPS]]|0.544|
|[[:human genes:h:hccs|HCCS]]|0.543|
|[[:human genes:r:rpia|RPIA]]|0.542|
|[[:human genes:p:ppcs|PPCS]]|0.54|
|[[:human genes:a:atp5a1|ATP5A1]]|0.538|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.538|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.536|
|[[:human genes:a:alg13|ALG13]]|0.534|
|[[:human genes:m:mrpl47|MRPL47]]|0.533|
|[[:human genes:d:dpagt1|DPAGT1]]|0.533|
|[[:human genes:i:iba57|IBA57]]|0.532|
|[[:human genes:g:gfm2|GFM2]]|0.531|
|[[:human genes:a:atp5j|ATP5J]]|0.531|
|[[:human genes:u:uap1|UAP1]]|0.53|
|[[:human genes:g:gatc|GATC]]|0.529|
|[[:human genes:p:pars2|PARS2]]|0.529|
|[[:human genes:q:qrsl1|QRSL1]]|0.528|
|[[:human genes:f:fh|FH]]|0.528|
|[[:human genes:m:mrpl53|MRPL53]]|0.526|
|[[:human genes:m:mrps21|MRPS21]]|0.526|
|[[:human genes:m:mrps2|MRPS2]]|0.526|
|[[:human genes:a:atp5d|ATP5D]]|0.525|
|[[:human genes:t:tamm41|TAMM41]]|0.525|
|[[:human genes:p:pnpt1|PNPT1]]|0.524|
|[[:human genes:t:tkt|TKT]]|0.523|
|[[:human genes:i:isca2|ISCA2]]|0.522|
|[[:human genes:t:tmem242|TMEM242]]|0.522|
|[[:human genes:f:fars2|FARS2]]|0.522|
|[[:human genes:m:mrps26|MRPS26]]|0.521|
|[[:human genes:n:ndufa3|NDUFA3]]|0.521|
|[[:human genes:e:elac2|ELAC2]]|0.52|
|[[:human genes:t:tars2|TARS2]]|0.52|
|[[:human genes:a:atp5o|ATP5O]]|0.518|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.517|
|[[:human genes:n:nars2|NARS2]]|0.517|
|[[:human genes:m:mrpl36|MRPL36]]|0.516|
|[[:human genes:e:ears2|EARS2]]|0.515|
|[[:human genes:m:mrps33|MRPS33]]|0.514|
|[[:human genes:c:c17orf89|C17orf89]]|0.514|
|[[:human genes:n:ndufb11|NDUFB11]]|0.512|
|[[:human genes:c:cycs|CYCS]]|0.511|
|[[:human genes:o:opa1|OPA1]]|0.508|
|[[:human genes:k:kctd5|KCTD5]]|0.505|
|[[:human genes:m:mrpl15|MRPL15]]|0.502|
|[[:human genes:g:gfpt1|GFPT1]]|0.502|
|[[:human genes:f:fastkd5|FASTKD5]]|0.501|
|[[:human genes:z:zrsr2|ZRSR2]]|0.5|
|[[:human genes:g:gmppb|GMPPB]]|0.499|
|[[:human genes:n:ndufb5|NDUFB5]]|0.499|
|[[:human genes:d:dhx30|DHX30]]|0.498|
|[[:human genes:c:coq3|COQ3]]|0.498|
|[[:human genes:p:ppa2|PPA2]]|0.497|
|[[:human genes:d:dhrsx|DHRSX]]|0.497|
|[[:human genes:p:pgm3|PGM3]]|0.494|
|[[:human genes:l:lonp1|LONP1]]|0.492|
|[[:human genes:m:mrps25|MRPS25]]|0.491|
|[[:human genes:m:mtg2|MTG2]]|0.49|
|[[:human genes:r:rars2|RARS2]]|0.49|
|[[:human genes:t:trmt5|TRMT5]]|0.488|
|[[:human genes:a:atp5h|ATP5H]]|0.486|
|[[:human genes:e:eno1|ENO1]]|0.486|
|[[:human genes:c:c10orf2|C10orf2]]|0.483|
|[[:human genes:m:mrpl27|MRPL27]]|0.483|
|[[:human genes:c:chchd4|CHCHD4]]|0.482|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.482|
|[[:human genes:m:mars2|MARS2]]|0.479|
|[[:human genes:t:timm13|TIMM13]]|0.479|
|[[:human genes:m:mrpl20|MRPL20]]|0.478|
|[[:human genes:m:mrps12|MRPS12]]|0.477|
|[[:human genes:t:timm8b|TIMM8B]]|0.477|
|[[:human genes:m:mtpap|MTPAP]]|0.477|
|[[:human genes:c:casp9|CASP9]]|0.475|
|[[:human genes:t:trmt10a|TRMT10A]]|0.474|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.473|
|[[:human genes:l:lars2|LARS2]]|0.473|
|[[:human genes:a:adsl|ADSL]]|0.472|
|[[:human genes:n:ndufb3|NDUFB3]]|0.472|
|[[:human genes:k:kdsr|KDSR]]|0.471|
|[[:human genes:a:alg5|ALG5]]|0.47|
|[[:human genes:r:rpusd3|RPUSD3]]|0.47|
|[[:human genes:u:uqcr10|UQCR10]]|0.469|
|[[:human genes:t:tefm|TEFM]]|0.468|
|[[:human genes:m:mrpl33|MRPL33]]|0.468|
|[[:human genes:c:cbfb|CBFB]]|0.465|
|[[:human genes:m:mrps23|MRPS23]]|0.465|
|[[:human genes:c:cox7b|COX7B]]|0.464|
|[[:human genes:m:mrps11|MRPS11]]|0.464|
|[[:human genes:m:mrps9|MRPS9]]|0.463|
|[[:human genes:c:cox6c|COX6C]]|0.463|
|[[:human genes:a:alg6|ALG6]]|0.462|
|[[:human genes:n:ndufa1|NDUFA1]]|0.461|
|[[:human genes:t:trub2|TRUB2]]|0.461|
|[[:human genes:r:rptor|RPTOR]]|0.46|
|[[:human genes:c:coq5|COQ5]]|0.46|
|[[:human genes:c:cep57|CEP57]]|0.46|
|[[:human genes:r:rtcb|RTCB]]|0.457|
|[[:human genes:g:gemin6|GEMIN6]]|0.456|
|[[:human genes:m:mrps36|MRPS36]]|0.456|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.455|
|[[:human genes:r:rfk|RFK]]|0.455|
|[[:human genes:c:coq2|COQ2]]|0.454|
|[[:human genes:m:mrpl12|MRPL12]]|0.45|
|[[:human genes:s:ssb|SSB]]|0.449|
|[[:human genes:a:atp5f1|ATP5F1]]|0.449|
|[[:human genes:t:trnt1|TRNT1]]|0.447|
|[[:human genes:t:ten1|TEN1]]|0.447|
|[[:human genes:m:mrpl22|MRPL22]]|0.446|
|[[:human genes:t:tomm40|TOMM40]]|0.446|
|[[:human genes:c:cbx3|CBX3]]|0.446|
|[[:human genes:c:cox17|COX17]]|0.446|
|[[:human genes:t:trmt61a|TRMT61A]]|0.444|
|[[:human genes:t:tomm22|TOMM22]]|0.443|
|[[:human genes:t:ttc4|TTC4]]|0.443|
|[[:human genes:n:ndufb9|NDUFB9]]|0.441|
|[[:human genes:u:ube2g2|UBE2G2]]|0.441|
|[[:human genes:e:exoc4|EXOC4]]|0.441|
|[[:human genes:m:mrpl42|MRPL42]]|0.44|
|[[:human genes:n:ndufc2|NDUFC2]]|0.44|
|[[:human genes:d:dr1|DR1]]|0.438|
|[[:human genes:n:nbn|NBN]]|0.438|
|[[:human genes:s:sdha|SDHA]]|0.436|
|[[:human genes:z:znhit1|ZNHIT1]]|0.436|
|[[:human genes:c:coa5|COA5]]|0.435|
|[[:human genes:u:utp23|UTP23]]|0.435|
|[[:human genes:t:tmem126b|TMEM126B]]|0.435|
|[[:human genes:s:srd5a3|SRD5A3]]|0.434|
|[[:human genes:a:aifm1|AIFM1]]|0.434|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.433|
|[[:human genes:r:rnmt|RNMT]]|0.433|
|[[:human genes:n:ndufb6|NDUFB6]]|0.433|
|[[:human genes:c:coa6|COA6]]|0.432|
|[[:human genes:m:mrpl39|MRPL39]]|0.432|
|[[:human genes:u:ube2k|UBE2K]]|0.432|
|[[:human genes:b:bak1|BAK1]]|0.431|
|[[:human genes:r:rpp21|RPP21]]|0.431|
|[[:human genes:p:plaa|PLAA]]|0.431|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.431|
|[[:human genes:b:bap1|BAP1]]|0.429|
|[[:human genes:e:elp3|ELP3]]|0.427|
|[[:human genes:m:mrpl45|MRPL45]]|0.427|
|[[:human genes:h:haus8|HAUS8]]|0.427|
|[[:human genes:m:mrpl3|MRPL3]]|0.425|
|[[:human genes:n:n6amt1|N6AMT1]]|0.425|
|[[:human genes:a:atp5sl|ATP5SL]]|0.425|
|[[:human genes:m:mtif3|MTIF3]]|0.424|
|[[:human genes:m:mrpl18|MRPL18]]|0.424|
|[[:human genes:g:gemin8|GEMIN8]]|0.423|
|[[:human genes:u:uqcrq|UQCRQ]]|0.422|
|[[:human genes:e:eif3f|EIF3F]]|0.421|
|[[:human genes:m:mrpl34|MRPL34]]|0.42|
|[[:human genes:t:txnl4b|TXNL4B]]|0.419|
|[[:human genes:b:brwd1|BRWD1]]|0.418|
|[[:human genes:t:tomm6|TOMM6]]|0.418|
|[[:human genes:l:lsm11|LSM11]]|0.418|
|[[:human genes:r:rabggtb|RABGGTB]]|0.418|
|[[:human genes:w:wdr24|WDR24]]|0.418|
|[[:human genes:c:cox15|COX15]]|0.417|
|[[:human genes:e:eny2|ENY2]]|0.417|
|[[:human genes:s:sec62|SEC62]]|0.416|
|[[:human genes:p:polg|POLG]]|0.416|
|[[:human genes:z:zcrb1|ZCRB1]]|0.415|
|[[:human genes:p:prkrir|PRKRIR]]|0.414|
|[[:human genes:g:gemin7|GEMIN7]]|0.414|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.413|
|[[:human genes:m:mrps10|MRPS10]]|0.413|
|[[:human genes:m:mis18a|MIS18A]]|0.413|
|[[:human genes:u:uba3|UBA3]]|0.413|
|[[:human genes:c:cept1|CEPT1]]|0.413|
|[[:human genes:c:cox5a|COX5A]]|0.412|
|[[:human genes:n:ndufa2|NDUFA2]]|0.412|
|[[:human genes:m:mtg1|MTG1]]|0.411|
|[[:human genes:a:apaf1|APAF1]]|0.411|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.411|
|[[:human genes:t:tmem41b|TMEM41B]]|0.409|
|[[:human genes:t:timm17a|TIMM17A]]|0.408|
|[[:human genes:c:coa3|COA3]]|0.408|
|[[:human genes:a:alg2|ALG2]]|0.408|
|[[:human genes:c:c16orf80|C16orf80]]|0.406|
|[[:human genes:g:g6pd|G6PD]]|0.406|
|[[:human genes:g:glmn|GLMN]]|0.405|
|[[:human genes:p:ptdss1|PTDSS1]]|0.405|
|[[:human genes:b:btf3|BTF3]]|0.404|
|[[:human genes:p:ppp6c|PPP6C]]|0.403|
|[[:human genes:m:mrps24|MRPS24]]|0.401|
|[[:human genes:r:rft1|RFT1]]|0.401|
|[[:human genes:t:tsen54|TSEN54]]|0.401|
|[[:human genes:n:nae1|NAE1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 48/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|4/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|2/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1108
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A26 Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>