SLC25A4 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A4
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=291|291]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12235|P12235]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. {ECO:0000269|PubMed:27693233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenine transmembrane transporter activity|
|adenine transport|
|ATP:ADP antiporter activity|
|ADP transport|
|purine nucleobase transport|
|integral component of mitochondrial membrane|
|nucleobase transport|
|negative regulation of necroptotic process|
|ATP transport|
|negative regulation of programmed necrotic cell death|
|adenine nucleotide transport|
|negative regulation of necrotic cell death|
|purine ribonucleotide transport|
|regulation of necroptotic process|
|purine nucleotide transport|
|mitochondrial genome maintenance|
|regulation of programmed necrotic cell death|
|nucleotide transport|
|regulation of necrotic cell death|
|apoptotic mitochondrial changes|
|carbohydrate derivative transport|
|organophosphate ester transport|
|drug transport|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|nucleobase-containing compound transport|
|regulation of hormone secretion|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|organic anion transport|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|anion transport|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of cell death|
|response to drug|
|regulation of protein localization|
|programmed cell death|
|cell death|
|mitochondrion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|regulation of programmed cell death|
|regulation of cell death|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13387
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A4 Expression in NALM6 Cells: 4.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>