SLC25A52 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A52 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A52
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 52
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=147407|147407]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3SY17|Q3SY17]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A52&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A52|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616153|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial inner membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.81|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.91|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.95|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.96|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.98|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.11|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.26|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.26|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.33|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.4|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.56|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.78|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.89|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.98|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.458|
|[[:human genes:n:ndufb11|NDUFB11]]|0.457|
|[[:human genes:n:ndufb9|NDUFB9]]|0.448|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.441|
|[[:human genes:n:ndufa2|NDUFA2]]|0.437|
|[[:human genes:a:atp5o|ATP5O]]|0.431|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.43|
|[[:human genes:d:dars2|DARS2]]|0.429|
|[[:human genes:n:nubpl|NUBPL]]|0.429|
|[[:human genes:a:atp5a1|ATP5A1]]|0.429|
|[[:human genes:b:bcs1l|BCS1L]]|0.428|
|[[:human genes:n:ndufc2|NDUFC2]]|0.427|
|[[:human genes:g:gatc|GATC]]|0.423|
|[[:human genes:p:pars2|PARS2]]|0.422|
|[[:human genes:a:atp5c1|ATP5C1]]|0.422|
|[[:human genes:m:mthfd1l|MTHFD1L]]|0.421|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.42|
|[[:human genes:m:mrpl21|MRPL21]]|0.419|
|[[:human genes:a:acad9|ACAD9]]|0.419|
|[[:human genes:l:lars2|LARS2]]|0.419|
|[[:human genes:r:rars2|RARS2]]|0.416|
|[[:human genes:n:nars2|NARS2]]|0.416|
|[[:human genes:w:wbscr16|WBSCR16]]|0.415|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.415|
|[[:human genes:n:ndufs2|NDUFS2]]|0.415|
|[[:human genes:d:dap3|DAP3]]|0.412|
|[[:human genes:q:qrsl1|QRSL1]]|0.411|
|[[:human genes:m:mrpl45|MRPL45]]|0.409|
|[[:human genes:a:atp5d|ATP5D]]|0.409|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.408|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.406|
|[[:human genes:m:mrps21|MRPS21]]|0.405|
|[[:human genes:p:polrmt|POLRMT]]|0.405|
|[[:human genes:p:pgm3|PGM3]]|0.404|
|[[:human genes:n:ndufb7|NDUFB7]]|0.404|
|[[:human genes:a:atp5b|ATP5B]]|0.403|
|[[:human genes:n:ndufb5|NDUFB5]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3196
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A52 Expression in NALM6 Cells: 0.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>